Biotin-PEG4-tetrazine

Biotinylation Tetrazines Copper-free click chemistry
Cat. # Quantity Price Lead time
3797-25mg 25 mg $210 in stock
3797-250mg 250 mg $1190 in stock
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Biotin-PEG4-tetrazine is a click chemistry biotinylation tool. The tetrazine group reacts extremely fast with terminal alkenes and trans-cyclooctenes via inverse electron demand Diels-Alder ligation (IEDDA). Tetrazines also react with some strained cycloalkynes.

Biotin-labeled compounds can be linked to avidin or streptavidin for further purification or detection. The biotin group is relatively small and doesn’t affect the biological activity of biotinylated proteins.

This reagent features a long PEG4-linker that separates the biotin residue from the target molecule, ensuring efficient binding to avidin or streptavidin. The linker also increases the compound’s water solubility, thereby facilitating bioconjugation.

Biotin-PEG4-tetrazine, 3797-250mg
Biotin-PEG4-tetrazine, 3797-250mg
Biotin-PEG4-tetrazine, 3797-250mg
Structure of Biotin-PEG4-Tetrazine
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Azide-PEG3-tetrazine

A hydrophilic bifunctional linker with azide and tetrazine function groups flanking PEG3 (triethylene glycol) spacer.
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General properties

Appearance: purple powder
Molecular weight: 674.83
Molecular formula: C31H46N8O7S
Solubility: good in water, DMSO, DMF
Quality control: NMR 1H and HPLC-MS (95+%)
Storage conditions: 24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Desiccate.
MSDS: Download
Product specifications
Product is offered and sold for research purposes only. Product is not tested for safety and efficacy in food, drug, medical device, cosmetic, no express or implied authorization to use for any other purpose, including, without limitation, in vitro diagnostic purposes, for humans or animals or for commercial purposes.
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