PROTAC in Applications
Proteolysis targeting chimeras (PROTACs) are cell-permeable heterobifunctional molecules that can remove specific proteins from the cell. One end of such molecule contains a ligand to bind to the target, and the second end recruits the E3 ligase complex. Close proximity results in substrate polyubiquitination and subsequent protein degradation by cellular proteasome.
Thalidomide-carboxylic acid
Thalidomide-containing building block with carboxylic acid functionality for convenient PROTAC molecule assembly by attachment amino-functionalized linkers and ligands to thalidomide via 4-O-position.
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Cat. # | Quantity | Price | Lead time | Buy this product |
---|---|---|---|---|
4169-100mg | 100 mg | $160 | in stock | |
4169-500mg | 500 mg | $510 | in stock | |
4169-1g | 1 g | $740 | in stock |
Thalidomide-O-PEG2-azide
Thalidomide-containing building block with PEG2-linker and azide function group for conjugation with alkyne-functionalized linkers and target protein ligands through click chemistry reactions.
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Cat. # | Quantity | Price | Lead time | Buy this product |
---|---|---|---|---|
4154-25mg | 25 mg | $189 | in stock | |
4154-100mg | 100 mg | $489 | in stock |
Thalidomide-O-PEG2-carboxylic acid
Thalidomide-containing building block with PEG2-linker and carboxylic group for conjugation with amino-functionalized linkers and target protein ligands.
Show pricing
Cat. # | Quantity | Price | Lead time | Buy this product |
---|---|---|---|---|
4192-25mg | 25 mg | $148 | in stock | |
4192-100mg | 100 mg | $480 | in stock |
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