(S,R,S)-AHPC-PEG2-C2-amine

Cat. # Quantity Price Lead time
4537-25mg 25 mg $189 in stock
4537-100mg 100 mg $489 in stock
4537-500mg 500 mg $1880 in stock
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Proteolysis targeting chimeras (PROTACs) are cell-permeable heterobifunctional molecules that can remove specific proteins from the cell. One end of such molecule contains a ligand to bind to the target, and the second end recruits the E3 ligase complex. Close proximity results in substrate polyubiquitination and subsequent protein degradation by cellular proteasome.

(S,R,S)-AHPC-C2-amine is a protein degrader building block for synthesizing molecules for targeted protein degradation and PROTAC technologies. This conjugate contains a von Hippel-Lindau (VHL)-recruiting ligand and a PEG2-C2 crosslinker with an amine function group, which can be conjugated to other functionalized linkers and target protein ligands.

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Degrader building block containing an E3 ligase ligand with linker and azide group, which can be conjugated to alkyne-functionalized linkers and target protein ligands through click chemistry reactions.

Thalidomide-O-PEG2-amine

Thalidomide-containing building block with PEG2-linker and amino group for conjugation with other functionalized linkers and target protein ligands.
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General properties

Appearance: beige powder
Molecular weight: 626.21
CAS number: 2138439-54-8
Molecular formula: C29H44ClN5O6S
Solubility: methanol, ethyl acetate, DCM, THF, DMF, DMSO
Quality control: NMR 1H and HPLC-MS (95+%)
Storage conditions: 24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Desiccate.
MSDS: Download
Product specifications
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