Bioconjugation reagents

Bioconjugation reagents / product groups & items in this category
Bioconjugation reagents: biotin, streptavidin, biotinylation reagents, bifunctional cross-linkers, PEG-linkers, auxiliary reagents for click chemistry, etc.

Activated esters (bifunctional)

Bifunctional activated NHS and STP esters for binding with primary and secondary amine groups.
Group tags Crosslinking, NHS esters, Cycloalkenes, Copper-free click chemistry, STP esters, Biotinylation, Cycloalkynes, Maleimides, Azides, Alkynes, Click chemistry, Protein labeling
  • 3-Maleimidopropionic acid NHS-ester
    Bifunctional crosslinker with an amine-reactive succinimidyl ester and a thiol-reactive maleimide group.
  • ATFB SE (N-Succinimidyl 4-Azidotetrafluorobenzoate)
    N-Succinimidyl 4-Azidotetrafluorobenzoate (ATFB SE, ATFB-OSu) is a photo-activatable linker used as a versatile labeling agent for investigating biological receptors.
  • Alkyne-PEG2-NHS ester
    Bifunctional hydrophilic linker with NHS ester and terminal alkyne functional group based on diethyleneglycol (PEG2).
  • Alkyne-PEG3-NHS ester
    Bifunctional hydrophilic linker with NHS ester and terminal alkyne functional group based on triethyleneglycol (PEG3).
  • Alkyne-PEG4-NHS ester
    Bifunctional hydrophilic linker with NHS ester and terminal alkyne functional group based on tetraethyleneglycol (PEG4).
  • Azide-PEG6-NHS ester
    A hydrophilic bifunctional linker with azide and NHS ester function groups flanking PEG6 (hexaethylene glycol).
  • Azidobutyric acid NHS ester
    Activated NHS ester for azido-labeling of peptides and proteins.
  • Biotin-PEG4-NHS ester
    PEG4-containing activated ester for simple and efficient biotin labeling of antibodies, proteins, and other primary amine-containing biomolecules.
  • Biotin-XX-NHS ester
    Biotin derivative with long spacer to reduce steric effect when binding amino acids, peptides, or proteins by reacting with primary amines.
  • DBCO-NHS ester
    Azodibenzocyclooctyne (DBCO, ADIBO) reagent for strain-promoted copper-free click chemistry (SPAAC). The reagent contains an NHS ester function for the attachment of the cyclooctyne to various molecules.
  • DBCO-PEG6-NHS ester
    A heterobifunctional linker with DBCO and NHS ester function groups flanking PEG6 (hexaethylene glycol).
  • DBCO-STP ester
    Activated ester for modification of proteins/antibodies/peptides followed by introduction into copper-free click chemistry reaction.
  • Disuccinimidyl glutarate (DSG)
    Homobifunctional crosslinker with two NHS ester groups at each end of a short 5-atom (7.7 angstrom) spacer.
  • Exo-BCN-PNP
    BCN-PNP carbonate is a tool to introduce BCN moety via carbamate linkage with primary amino groups of substrate.
  • Hexynoic acid NHS ester
    Hexynoic acid NHS ester for the labeling of biomolecules with alkyne group for copper-catalyzed click chemistry.
  • Hexynoic acid STP ester
    Alkyne activated ester for the modification of amine groups. STP ester group is an excellent alternative to NHS ester functionality.
  • Pentynoic acid STP ester
    An activated ester for the introduction of alkyne into peptides/proteins and click reaction.
  • TCO-PEG4-NHS ester (axial isomer)
    A heterobifunctional linker with trans-cyclooctene and NHS ester groups flanking PEG4 (tetraethylene glycol) for labeling of antibodies, proteins, and other primary amine-containing biomolecules.

Alkynes

Various terminal alkynes for сlick сhemistry. Fluorescent dye alkynes are listed under 'Reactive dyes' category.
Group tags Crosslinking, NHS esters, STP esters, Biotinylation, Maleimides, Carboxylic acids, Alkynes, Halides, Hydrazides, Click chemistry, Protein labeling, Amines
  • Alkyne hydrazide
    Bifunctional reagent containing alkyne group and hydrazide function. It reacts with aldehydes and ketones. Alkyne group can then be coupled with various azides via CuAAC reaction.
  • Alkyne maleimide
    Maleimide reagent for the attachment of alkyne functional group to proteins, peptides, and other molecules bearing SH (thiol) groups, including cysteine residues.
  • Alkyne-PEG2-NHS ester
    Bifunctional hydrophilic linker with NHS ester and terminal alkyne functional group based on diethyleneglycol (PEG2).
  • Alkyne-PEG2-amine
    Diethyleneglycol (PEG2) based bifunctional linker containing amine and alkyne functional groups.
  • Alkyne-PEG2-carboxylic acid
    Bifunctional diethyleneglycol linker with terminal alkyne and carboxylic acid moieties.
  • Alkyne-PEG2-iodide
    Bifunctional reactive crosslinker containing terminal alkyne group for click chemistry or Sonogashira coupling, and reactive alkyl iodide group.
  • Alkyne-PEG3-NHS ester
    Bifunctional hydrophilic linker with NHS ester and terminal alkyne functional group based on triethyleneglycol (PEG3).
  • Alkyne-PEG3-OH
    Alkyne-PEG3-OH is a triethyleneglycol based bifunctional linker with a hydroxyl group and an alkyne fragment.
  • Alkyne-PEG3-amine
    Alkyne-PEG3-amine is a medium-length heterobifunctional linker for conjugation.
  • Alkyne-PEG3-carboxylic acid
    Bifunctional triethyleneglycol linker with terminal alkyne and carboxylic acid moieties.
  • Alkyne-PEG3-iodide
    PEG3 with alkyne and iodide functional groups, a reactive and hydrophilic linker for alkylation and click chemistry.
  • Alkyne-PEG3-maleimide
    Bifunctional spacer with alkyne and maleimide groups for conjugation of biomolecules.
  • Alkyne-PEG4-NHS ester
    Bifunctional hydrophilic linker with NHS ester and terminal alkyne functional group based on tetraethyleneglycol (PEG4).
  • Alkyne-PEG4-amine
    A bifunctional linker molecule containing both terminal alkyne moiety for click chemistry, and amine group. Contains a long hydrophilic PEG4 arm.
  • Alkyne-PEG4-carboxylic acid
    Bifunctional tetraethyleneglycol linker with terminal alkyne and carboxylic acid moieties.
  • Alkyne-PEG4-iodide
    Bifunctional reactive PEG4-based crosslinker containing terminal alkyne group for click chemistry or Sonogashira coupling and reactive alkyl iodide group.
  • Alkyne-PEG4-maleimide
    Water soluble, heterobifunctional hydrophilic linker with a length of 14 Å, containing maleimide for thiol labeling, and alkyne for click chemistry. An ideal reagent to attach an alkyne moiety to a protein.
  • Biotin-PEG2-alkyne
    Biotin alkyne is a reagent for click chemistry labeling with biotin, an affinity probe to streptavidin.
  • Biotin-PEG4-alkyne
    Biotin alkyne is a reagent for click chemistry labeling with biotin, an affinity probe to streptavidin.
  • Hexynoic acid NHS ester
    Hexynoic acid NHS ester for the labeling of biomolecules with alkyne group for copper-catalyzed click chemistry.
  • Hexynoic acid STP ester
    Alkyne activated ester for the modification of amine groups. STP ester group is an excellent alternative to NHS ester functionality.
  • Pentynoic acid STP ester
    An activated ester for the introduction of alkyne into peptides/proteins and click reaction.

Cycloalkenes

Cycloalkenes for copper-free alkene-tetrazine click reaction.
Group tags NHS esters, Cycloalkenes, Copper-free click chemistry, Protein labeling
  • TCO-PEG4-NHS ester (axial isomer)
    A heterobifunctional linker with trans-cyclooctene and NHS ester groups flanking PEG4 (tetraethylene glycol) for labeling of antibodies, proteins, and other primary amine-containing biomolecules.

Amines

Amines for the coupling with various electrophilic compounds like activated esters and epoxides.
Group tags Crosslinking, PROTAC, Copper-free click chemistry, Biotinylation, Cycloalkynes, Carboxylic acids, Azides, Alkynes, Click chemistry, Amines
  • (S,R,S)-AHPC-PEG2-C2-amine
    Degrader building block containing an E3 ligase ligand with linker and amino group for conjugation with other functionalized linkers and target protein ligands.
  • 3-Azidopropylamine hydrochloride
    A bifunctional short linker with amino and azido groups. A solid, chemically stable hydrochloride form of azidopropylamine. This product is ideal as an azidopropylamine bulk for applications when a large amount of reagent is needed.
  • Alkyne-PEG2-amine
    Diethyleneglycol (PEG2) based bifunctional linker containing amine and alkyne functional groups.
  • Alkyne-PEG3-amine
    Alkyne-PEG3-amine is a medium-length heterobifunctional linker for conjugation.
  • Alkyne-PEG4-amine
    A bifunctional linker molecule containing both terminal alkyne moiety for click chemistry, and amine group. Contains a long hydrophilic PEG4 arm.
  • Amine-PEG2-carboxylic acid
    Hydrophilic PEG2-linker with a terminal amino group and a carboxyl group.
  • Amine-PEG3-OH
    Bifunctional PEG3 derivative with amine and hydroxyl groups.
  • Amine-PEG3-carboxylic acid
    Hydrophilic PEG3-linker with a terminal amino group and a carboxyl group.
  • Amine-PEG4-OH
    A hydrophilic tetraethylene glycol derivative with terminal amino and hydroxyl groups.
  • Amine-PEG4-carboxylic acid
    Hydrophilic PEG4-linker with a terminal amino group and a carboxyl group.
  • Amine-PEG6-OH
    A hydrophilic hexaethylene glycol derivative with terminal amino and hydroxyl groups.
  • Azide-PEG2-amine
    A diethylene glycol (PEG2) linker with azide and amino groups.
  • Azide-PEG3-amine
    A bifunctional linker with azide and amine groups flanking PEG3 (triethylene glycol)
  • Azide-PEG4-amine
    PEG4 amine azide is a bifunctional linker with amine and azide functional groups. It is based on a tetraethyleneglycol core. The length of the PEG4 linker is 1.4 nm.
  • Biotin-PEG2-amine
    Diethylene glycol (PEG2) based bifunctional molecule containing biotin and amine functional group.
  • Biotin-PEG3-amine
    Triethylene glycol (PEG3) based bifunctional molecule containing biotin and amine functional group.
  • Biotin-PEG4-amine
    Tetraethylene glycol (PEG4) based bifunctional molecule containing biotin and amine functional group.
  • DBCO-amine trifluoroacetate
    Bifunctional linker containing dibenzocyclooctyne (DBCO, ADIBO) for strain-promoted copper-free click reaction (SPAAC) and free amine for the coupling with various electrophilic compounds like activated esters and epoxides.
  • Tetraglycine hydrochloride
    Tetraglycine is an oligopeptide composed of four glycine monomers. It is used as a bifunctional linker with amino and carboxyl groups.
  • Thalidomide-O-PEG2-amine
    Thalidomide-containing building block with PEG2-linker and amino group for conjugation with other functionalized linkers and target protein ligands.
  • VHL Ligand 1 dihydrochloride
    VHL Ligand 1 is a building block for synthesizing proteolysis-targeting chimera (PROTAC) molecules.

Azides

Various non-fluorescent azides for click chemistry. Fluorescent azides are listed under Reactive dyes category.
Group tags Crosslinking, PROTAC, NHS esters, Copper-free click chemistry, Tetrazines, Biotinylation, Maleimides, Carboxylic acids, Azides, Halides, Click chemistry, Protein labeling, Amines
  • Azide-PEG4-maleimide kit
    Azide-PEG4-maleimide (two-component composition) - bifunctional reagent with PEG spacer, enabling conjugation with biomolecule thiol residues and click chemistry reactions.
  • (S,R,S)-AHPC-PEG2-C2-azide
    Degrader building block containing an E3 ligase ligand with linker and azide group, which can be conjugated to alkyne-functionalized linkers and target protein ligands through click chemistry reactions.
  • 3-Azidopropanol
    Azidopropanol is a short bifunctional linker compound with azide and hydroxyl functional groups.
  • 3-Azidopropylamine
    Water-soluble, bifunctional short crosslinker with amino and azide groups.
  • 3-Azidopropylamine hydrochloride
    A bifunctional short linker with amino and azido groups. A solid, chemically stable hydrochloride form of azidopropylamine. This product is ideal as an azidopropylamine bulk for applications when a large amount of reagent is needed.
  • ATFB SE (N-Succinimidyl 4-Azidotetrafluorobenzoate)
    N-Succinimidyl 4-Azidotetrafluorobenzoate (ATFB SE, ATFB-OSu) is a photo-activatable linker used as a versatile labeling agent for investigating biological receptors.
  • Azide-PEG2-amine
    A diethylene glycol (PEG2) linker with azide and amino groups.
  • Azide-PEG2-carboxylic acid
    Bifunctional diethylene glycol with terminal carboxyl and azido groups.
  • Azide-PEG2-iodide
    A bifunctional molecule containing hydrophilic PEG2 with azide and iodide groups.
  • Azide-PEG3-OH
    Azide-PEG3-OH is a bifunctional molecule with an azide group, primary alcohol, and a hydrophilic PEG3 linker in between.
  • Azide-PEG3-amine
    A bifunctional linker with azide and amine groups flanking PEG3 (triethylene glycol)
  • Azide-PEG3-azide
    Triethylene glycol diazide is a bifunctional crosslinker bearing two azide groups. Suitable for click chemistry.
  • Azide-PEG3-carboxylic acid
    Bifunctional triethylene glycol with terminal carboxyl and azido groups.
  • Azide-PEG3-chloride
    Azide-PEG3-chloride contains a reactive halogen atom and an azide group for click chemistry reaction. It can also serve as a protected amine group equivalent.
  • Azide-PEG3-iodide
    Azide-PEG3-iodide is a bifunctional linker with a highly reactive alkylative halogen functional group and an azido group for click chemistry or Staudinger ligation.
  • Azide-PEG3-tetrazine
    A hydrophilic bifunctional linker with azide and tetrazine function groups flanking PEG3 (triethylene glycol) spacer.
  • Azide-PEG4-OH
    Azide-PEG4-OH is a bifunctional molecule with an azide group, primary alcohol, and a hydrophilic PEG4 linker in between.
  • Azide-PEG4-amine
    PEG4 amine azide is a bifunctional linker with amine and azide functional groups. It is based on a tetraethyleneglycol core. The length of the PEG4 linker is 1.4 nm.
  • Azide-PEG4-azide
    PEG4 diazide is a homobifunctional linker with two azide groups. It can be used for the synthesis of dimeric molecules with a hydrophilic core by click chemistry.
  • Azide-PEG4-carboxylic acid
    Bifunctional tetraethylene glycol with terminal carboxyl and azido groups.
  • Azide-PEG6-NHS ester
    A hydrophilic bifunctional linker with azide and NHS ester function groups flanking PEG6 (hexaethylene glycol).
  • Azide-PEG6-OH
    Water-soluble heterobifunctional crosslinker with a primary hydroxyl group, alkyne-reactive azide group, and a PEG6 hydrophilic linker.
  • Azidobutyric acid NHS ester
    Activated NHS ester for azido-labeling of peptides and proteins.
  • Biotin-PEG4-azide
    Biotin azide is a reagent for click chemistry labeling with biotin, a well-known affinity probe to streptavidin.
  • Thalidomide-O-PEG2-azide
    Thalidomide-containing building block with PEG2-linker and azide function group for conjugation with alkyne-functionalized linkers and target protein ligands through click chemistry reactions.

Biotin and streptavidin

Biotin derivatives with different spacers for introducing biotin labels into proteins, antibodies, and nucleic acids. Fluorescent dye conjugates of biotin and streptavidin.
Group tags AF 488, Crosslinking, NHS esters, Copper-free click chemistry, Tetrazines, Biotinylation, AF 594, Maleimides, Carboxylic acids, Neuroscience, Azides, Flow cytometry, Alkynes, Halides, Hydrazides, sulfo-Cyanine3, Microscopy, Click chemistry, Super-resolution imaging, sulfo-Cyanine5, Protein labeling, Amines, AMCA
  • AF 488 streptavidin
    AF 488 conjugate of streptavidin, a high-affinity biotin-binding protein, for immunofluorescence, western blots, microplate assays, and other applications use.
  • AF 594 streptavidin
    AF 594 conjugate of streptavidin, a high-affinity biotin-binding protein, for immunofluorescence, western blots, microplate assays, and other applications use.
  • AMCA streptavidin
    AMCA conjugate of streptavidin, a high-affinity biotin-binding protein, for immunofluorescence, western blots, microplate assays, and other applications use.
  • Biocytin hydrochloride
    Lysine derivative of biotin for conjugation with avidin or streptavidin, neuroanatomical tracer.
  • Biotin alkyne
    Biotin alkyne is a reactive affinity label which can be attached to biomolecules via click reaction.
  • Biotin-PEG2-alkyne
    Biotin alkyne is a reagent for click chemistry labeling with biotin, an affinity probe to streptavidin.
  • Biotin-PEG2-azide
    Biotin azide is a reagent for click chemistry labeling with biotin, a well-known affinity probe to streptavidin.
  • Biotin-PEG3-OH
    Bifunctional triethyleneglycol linker with biotin and hydroxyl moieties.
  • Biotin-PEG3-amine
    Triethylene glycol (PEG3) based bifunctional molecule containing biotin and amine functional group.
  • Biotin-PEG3-azide
    Biotin azide is a reagent for click chemistry labeling with biotin, a well-known affinity probe to streptavidin.
  • Biotin-PEG4-NHS ester
    PEG4-containing activated ester for simple and efficient biotin labeling of antibodies, proteins, and other primary amine-containing biomolecules.
  • Biotin-PEG4-alkyne
    Biotin alkyne is a reagent for click chemistry labeling with biotin, an affinity probe to streptavidin.
  • Biotin-PEG4-amine
    Tetraethylene glycol (PEG4) based bifunctional molecule containing biotin and amine functional group.
  • Biotin-PEG4-azide
    Biotin azide is a reagent for click chemistry labeling with biotin, a well-known affinity probe to streptavidin.
  • Biotin-PEG4-carboxylic acid
    Bifunctional tetraethyleneglycol linker with biotin and carboxylic acid moieties.
  • Biotin-PEG4-iodide
    A highly reactive biotinylation reagent that readily and efficiently interacts with various nucleophiles.
  • Biotin-PEG4-tetrazine
    Biotin tetrazine is a reagent for copper-free click chemistry labeling with biotin, a well-known affinity probe to streptavidin.
  • Biotin-X-NHS ester
    Biotin derivative with C6-spacer to reduce steric effect when binding amino acids, peptides, or proteins by reacting with primary amines.
  • Biotin-X-hydrazide
    Hydrazide biotin reagent with aminocaproic spacer useful for biotinylation of macromolecule reactive carbonyls.
  • Biotin-X-maleimide
    Thiol-reactive bifunctional linker for attaching biotin to proteins, peptides, and other thiolated molecules.
  • Biotin-XX-NHS ester
    Biotin derivative with long spacer to reduce steric effect when binding amino acids, peptides, or proteins by reacting with primary amines.
  • Biotin-cystamine hydrochloride
    Biotin and cystamine conjugate is a cleavable biotinylation reagent.
  • sulfo-Cyanine3 streptavidin
    sulfo-Cyanine3 conjugate of streptavidin, a high-affinity biotin-binding protein, for immunofluorescence, western blots, microplate assays, and other applications use.
  • sulfo-Cyanine3-PEG3-biotin
    Conjugate of hydrophilic sulfo-Cyanine3 dye with biotin, affinity label for avidin/streptavidin.
  • sulfo-Cyanine5 streptavidin
    sulfo-Cyanine5 conjugate of streptavidin, a high-affinity biotin-binding protein, for immunofluorescence, western blots, microplate assays, and other applications use.
  • sulfo-Cyanine5-PEG3-biotin
    Biotin conjugate of the far-red fluorescent sulfo-Cyanine5 dye.

Hydrazides

Hydrazides are carbonyl-reactive reagents for the labeling of aldehydes and ketones.
Group tags Crosslinking, Biotinylation, Azides, Alkynes, Hydrazides, Click chemistry, Protein labeling
  • Alkyne hydrazide
    Bifunctional reagent containing alkyne group and hydrazide function. It reacts with aldehydes and ketones. Alkyne group can then be coupled with various azides via CuAAC reaction.
  • Azide-PEG4-hydrazide
    A bifunctional reagent containing the azide group and hydrazide function. It reacts with aldehydes and ketones. The azide group can then be coupled with various alkynes via CuAAC reaction.
  • Biotin-X-hydrazide
    Hydrazide biotin reagent with aminocaproic spacer useful for biotinylation of macromolecule reactive carbonyls.

Tetrazines

Non-fluorescent tetrazines for inverse electron demand Diels-Alder reaction (IEDDA) with terminal alkenes and strained olefins, such as trans-cyclooctenes and some cyclooctynes.
Group tags Crosslinking, Copper-free click chemistry, Tetrazines, Biotinylation, Azides, Click chemistry
  • Azide-PEG3-tetrazine
    A hydrophilic bifunctional linker with azide and tetrazine function groups flanking PEG3 (triethylene glycol) spacer.
  • Biotin-PEG4-tetrazine
    Biotin tetrazine is a reagent for copper-free click chemistry labeling with biotin, a well-known affinity probe to streptavidin.
  • PEG3-tetrazine
    PEG3 tetrazine is a mono-reactive triethyleneglycol with a tetrazine group for IEDDA conjugation with strained olefins.

Carboxylic acids

Carboxylic acids with reactive groups for the conjugation of different biomolecules.
Group tags Crosslinking, PROTAC, Carboxylic acids, Azides, Alkynes, Halides, Click chemistry, Amines

Halides

Halogen derivatives with reactive groups for bioconjugation.
Group tags Crosslinking, Carboxylic acids, Azides, Alkynes, Halides, Click chemistry
  • Alkyne-PEG2-iodide
    Bifunctional reactive crosslinker containing terminal alkyne group for click chemistry or Sonogashira coupling, and reactive alkyl iodide group.
  • Alkyne-PEG3-iodide
    PEG3 with alkyne and iodide functional groups, a reactive and hydrophilic linker for alkylation and click chemistry.
  • Alkyne-PEG4-iodide
    Bifunctional reactive PEG4-based crosslinker containing terminal alkyne group for click chemistry or Sonogashira coupling and reactive alkyl iodide group.
  • Azide-PEG2-iodide
    A bifunctional molecule containing hydrophilic PEG2 with azide and iodide groups.
  • Azide-PEG3-chloride
    Azide-PEG3-chloride contains a reactive halogen atom and an azide group for click chemistry reaction. It can also serve as a protected amine group equivalent.
  • Azide-PEG3-iodide
    Azide-PEG3-iodide is a bifunctional linker with a highly reactive alkylative halogen functional group and an azido group for click chemistry or Staudinger ligation.
  • Iodo-PEG3-carboxylic acid
    A bifunctional compound containing carboxylic acid functional group, and iodide, an active halogen group.
  • Iodo-PEG3-iodide
    Homobifunctional PEG3 based linker with halogen reactive groups is useful for the crosslinking of nucleophiles.

Click chemistry ligands and catalysts

Auxiliary reagents for click chemistry: catalysts, buffers, and ligands for copper-catalyzed click reaction (CuAAC).
Group tags Click chemistry
  • Ascorbic acid
    Ascorbic acid is a reducing agent converting copper(II) into a monovalent form that catalyzes the click reaction.
  • BTTAA ligand
    BTTAA is the newest generation of water-soluble ligands for the copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC) that dramatically accelerates reaction rates and suppresses cell cytotoxicity.
  • Copper(II)-BTTAA complex
    A catalyst for copper-catalyzed click reactions in aqueous media. A stable сopper(II) complex with BTTAA which must be converted to copper(I) using reducing agents. The complex can be used to prepare a reaction buffer of any composition.
  • Copper(II)-TBTA complex
    A catalyst for click reaction. A stable copper(II) complex which must be converted to monovalent copper(I) in situ using reducing agents. The complex can be used to prepare a reaction buffer of any composition.
  • Copper(II)-THPTA catalytic buffer, 1.5x
    Ready-to-use catalytic buffer containing сopper(II) and water-soluble THPTA ligand. It is suitable for click chemistry modification of proteins.
  • Copper(II)-TВTA catalytic buffer, 1.5x
    Ready-to-use catalytic buffer containing сopper(II) and TBTA ligand. It is suitable for click chemistry modification of nucleic acids and small molecules.
  • TBTA ligand
    TBTA is one of the most widely used water-insoluble ligands for copper-catalyzed azide-alkyne cycloadditions (CuAAC).
  • THPTA ligand
    THPTA is a water-soluble ligand for Cu(I)-catalyzed click chemistry. The ligand stabilizes copper in its Cu(I) oxidation state. Due to high aqueous solubility, reactions with this ligand do not require an organic co-solvent.

Auxiliary reagents for bioconjugation

Auxiliary reagents, various buffers, and solvents for labeling and conjugation.
Group tags Click chemistry

Homobifunctional reagents

Homobifunctional crosslinkers with identical reactive groups at opposite ends of the spacer for intramolecular crosslinks and chemical crosslinking of macromolecular chains.
Group tags Crosslinking, NHS esters, Carboxylic acids, Azides, Halides, Click chemistry
  • Azide-PEG3-azide
    Triethylene glycol diazide is a bifunctional crosslinker bearing two azide groups. Suitable for click chemistry.
  • Azide-PEG4-azide
    PEG4 diazide is a homobifunctional linker with two azide groups. It can be used for the synthesis of dimeric molecules with a hydrophilic core by click chemistry.
  • Disuccinimidyl glutarate (DSG)
    Homobifunctional crosslinker with two NHS ester groups at each end of a short 5-atom (7.7 angstrom) spacer.
  • Iodo-PEG3-iodide
    Homobifunctional PEG3 based linker with halogen reactive groups is useful for the crosslinking of nucleophiles.
  • PEG3-dicarboxylic acid
    PEG3-dicarboxylic acid is a bifunctional linker carrying two carboxy groups. It contains a polyethyleneglycol-3 linker between the carboxyls.

Maleimides

Maleimides are thiol-reactive compounds for labeling sulfhydryl (thiol) groups in proteins.
Group tags Crosslinking, NHS esters, Copper-free click chemistry, Biotinylation, Cycloalkynes, Maleimides, Azides, Alkynes, Click chemistry
  • Azide-PEG4-maleimide kit
    Azide-PEG4-maleimide (two-component composition) - bifunctional reagent with PEG spacer, enabling conjugation with biomolecule thiol residues and click chemistry reactions.
  • 3-Maleimidopropionic acid NHS-ester
    Bifunctional crosslinker with an amine-reactive succinimidyl ester and a thiol-reactive maleimide group.
  • Alkyne maleimide
    Maleimide reagent for the attachment of alkyne functional group to proteins, peptides, and other molecules bearing SH (thiol) groups, including cysteine residues.
  • Alkyne-PEG3-maleimide
    Bifunctional spacer with alkyne and maleimide groups for conjugation of biomolecules.
  • Alkyne-PEG4-maleimide
    Water soluble, heterobifunctional hydrophilic linker with a length of 14 Å, containing maleimide for thiol labeling, and alkyne for click chemistry. An ideal reagent to attach an alkyne moiety to a protein.
  • Biotin-X-maleimide
    Thiol-reactive bifunctional linker for attaching biotin to proteins, peptides, and other thiolated molecules.
  • DBCO-maleimide
    Bifunctional linker containing a thiol-reactive maleimide group and an azide-reactive dibenzocyclooctyne moiety.

Cycloalkynes

Highly reactive cycloalkynes for copper-free click reaction (SPAAC, strain-promoted azide-alkyne cycloaddition).
Group tags Crosslinking, NHS esters, Copper-free click chemistry, STP esters, Cycloalkynes, Maleimides, Cyanine3, Click chemistry, Protein labeling, Amines
  • Cyanine3-PEG4-BCN (exo)
    Cyanine3-PEG4-BCN is an ethylene glycol separated linker for the azido-modified molecules for copper-free click conjugation.
  • DBCO-NHS ester
    Azodibenzocyclooctyne (DBCO, ADIBO) reagent for strain-promoted copper-free click chemistry (SPAAC). The reagent contains an NHS ester function for the attachment of the cyclooctyne to various molecules.
  • DBCO-PEG6-NHS ester
    A heterobifunctional linker with DBCO and NHS ester function groups flanking PEG6 (hexaethylene glycol).
  • DBCO-STP ester
    Activated ester for modification of proteins/antibodies/peptides followed by introduction into copper-free click chemistry reaction.
  • DBCO-amine trifluoroacetate
    Bifunctional linker containing dibenzocyclooctyne (DBCO, ADIBO) for strain-promoted copper-free click reaction (SPAAC) and free amine for the coupling with various electrophilic compounds like activated esters and epoxides.
  • DBCO-maleimide
    Bifunctional linker containing a thiol-reactive maleimide group and an azide-reactive dibenzocyclooctyne moiety.
  • Exo-BCN-PNP
    BCN-PNP carbonate is a tool to introduce BCN moety via carbamate linkage with primary amino groups of substrate.

Thiols

Bifunctional reagents with a thiol (-SH) functional group. Thiols are nucleophilic compounds that participate in many reactions with electrophiles.
Group tags Crosslinking, Thiols
  • Hydroxy-PEG2-thiol
    Short bifunctional linker with thiol and hydroxyl groups. Thiol can coat gold surfaces forming a hydrophilic monolayer.
  • Hydroxy-PEG3-thiol
    PEG3 bifunctional linker with thiol and hydroxyl groups. Thiol can coat gold surfaces forming a hydrophilic monolayer.
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