Alkyne-PEG3-carboxylic acid

Alkynes Click chemistry Crosslinking Carboxylic acids
Cat. # Quantity Price Lead time
1743-1g 1 g $490 in stock
1743-5g 5 g $980 in stock
1743-25g 25 g please inquire in stock
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Items in stock will be shipped on 06/09/2025
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Alkyne-PEG3-carboxylic acid is a bifunctional triethyleneglycol derivative bearing a carboxy group and an alkyne moiety. The former can be activated with peptide coupling reagents like PyBOP or carbodiimides like EDC to form a stable amide linkage with amines. The alkyne group can be coupled with azides in a CuAAC reaction.

PEGs are hydrophilic linkers useful in synthesizing water-soluble conjugates.

Alkyne-PEG3-COOH, 1743-1g
Alkyne-PEG3-COOH, 1743-1g
Alkyne-PEG3-COOH, 1743-1g
Structure of Alkyne-PEG3-acid, CAS 1415800-32-6
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Alkyne-PEG4-carboxylic acid

Bifunctional tetraethyleneglycol linker with terminal alkyne and carboxylic acid moieties.

Azide-PEG3-azide

Triethylene glycol diazide is a bifunctional crosslinker bearing two azide groups. Suitable for click chemistry.

General properties

Appearance: colorless to yellow oil
Molecular weight: 246.26
CAS number: 1415800-32-6
Molecular formula: C11H18O6
IUPAC name: 3,6,9,12-tetraoxapentadecyn-15-oic acid
Solubility: good in most organic solvents and water
Quality control: NMR 1H, GC-MS (95%, as Me ester)
Storage conditions: Storage: 24 months after receival at -20°C. Transportation: at room temperature for up to 3 weeks. Desiccate.
MSDS: Download
Product specifications

Product citations

  1. Petrov, R.A.; Mefedova, S.R.; Yamansarov, E.Y.; Maklakova, S.Y.; Grishin, D.A.; Lopatukhina, E.V.; Burenina, O.Y.; Lopukhov, A.V.; Kovalev, S.V.; Timchenko, Y.V.; Ondar, E.E.; Ivanenkov, Y.A.; Evteev, S.A.; Vaneev, A.N.; Timoshenko, R.V.; Klyachko, N.L.; Erofeev, A.S.; Gorelkin, P.V.; Beloglazkina, E.K.; Majouga, A.G. New Small-Molecule Glycoconjugates of Docetaxel and GalNAc for Targeted Delivery to Hepatocellular Carcinoma. Molecular Pharmaceutics, 2021, 18(1), 461–468. doi: 10.1021/acs.molpharmaceut.0c00980
This Product is offered and sold for research purposes only. It has not been tested for safety and efficacy in food, drug, medical device, cosmetic, commercial or any other use. Supply does not express or imply authorization to use for any other purpose, including, without limitation, in vitro diagnostic purposes, in the manufacture of food or pharmaceutical products, in medical devices or in cosmetic products.
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