Conjugation of Alkyne- or Azide-modified Proteins with Dye Azides or Alkynes
Intended for the CuAAC reaction with proteins, protein labeling buffer protects biomolecules from being damaged by reactive oxygen species. This reaction can be used for proteins with alkyne or azide groups, as well as cells or components of cell lysates metabolically labeled with azide groups.
Azide is conjugated to terminal alkyne, resulting in a five-membered heterocycle (1,2,3-triazole). Both groups (azide and alkyne) are extremely rarely found in natural biomolecules, so the reaction is highly specific and effective to handle various tasks.
The reaction proceeds in the presence of copper (I) compounds and almost does not depend on pH. Optimized for operations with proteins, protein labeling buffer contains a salt of copper (II) (a stable precursor of catalytically-active copper (I) compounds), triethylammonium acetate pH 6.8, water-soluble THPTA ligand, and aminoguanidine. It is recommended to use a freshly prepared solution of ascorbic acid to reduce copper (II). THPTA ligand in protein labeling buffer speeds up the reaction by stabilizing catalytically-active compounds of copper (I). The presence of THPTA ligand also allows protein labeling in water medium (without organic solvents) and, owing to stabilization of copper (I) oxidation degree, minimizes production of reactive oxygen species (RAS) and prevents them from damaging proteins by oxidizing histidine, methionine and cysteine. Aminoguanidine in protein labeling buffer prevents chemically reactive aldehydes (dehydroascorbate hydrolysis products) from binding to side chains of arginine, N-terminal cysteine, and lysine.
For this reaction, you will need alkyne- or azide-modified protein in azide sodium-free buffer, dye azide or alkyne, 1.5х protein labeling buffer, and ascorbic acid. It is recommended to perform steps 6 to 9 under an inert gas (nitrogen or argon).
Protocol
We recommend the following protocol for conjugation of modified proteins with dye derivatives:
- Determine total reaction volume based on the amount of modified protein to be used:
! The volume of alkyne- or azide-modified protein solution should be not more than 1/3 of total
reaction volume.
Total reaction volume, µL Amount of protein 100 4 to 20 nmol 200 20 to 40 nmol 400 40 to 80 nmol 600 80 to 600 nmol - Calculate volumes of the reagents for the labeling reaction using the table below:
* the dye excess may vary depending on the number of azide or alkyne groups on the protein molecule. Calculations in the table are shown for 3x excess of the dye. For 1.5–10x excess of the dye, multiply protein amount (nmol) by 0.15–1. But remember that if you use an azide or alkyne that is not soluble in water, in a big excess it may precipitate from the reaction mixture. Use water-soluble dyes, for example, sulfonated cyanine dyes sulfo-Cyanine.
Reagent Volume, µL Concentration of stock solution Dye azide or alkyne (amount of protein [nmol]) × 0.3* 10 mM in DMSO or water Protein labeling buffer (total reaction volume [µL]) × 0.67 1.5х Activator (ascorbic acid) (total reaction volume [µL]) × 0.02 50 mM in water Water (total reaction volume [µL] – volume of dye solution [µL] – volume of protein labeling buffer [µL] – volume of activator solution [µL]) — - Prepare stock solution of dye azide or alkyne (10 mM in DMSO or water, for water-soluble alkynes and azides) and activator (ascorbic acid, 50 mM in water). Bear in mind that ascorbic acid is readily oxidizable in air. Use only a freshly prepared solution of activator (the solution is stable within 1 day). To prepare stock solution, dissolve 10 mg of ascorbic acid in 1.1 mL of water.
- Add protein labeling buffer to modified protein solution and vortex.
- Add the calculated volume of stock solution of dye azide or alkyne and vortex well again.
- (recommended) Degas the mixture to remove oxygen. To do so, connect a disposable pipette tip to a plastic or silicone tubing connected to the pressure regulator of a gas cylinder with inert gas (argon or nitrogen). Turn on a very weak gas flow and put the tip down in the tube so that it can be 3–10 mm higher than the liquid level avoiding touching the liquid and tube walls. The gas flow should make a swirl in the liquid without spattering it. Keep the tip in this position for 10–20 seconds. If several labeling reactions are run simultaneously, a centrifugal concentrator can be used for degassing. To do so, place the tubes in the concentrator, turn on rotation, turn on vacuum for 30–40 seconds, then turn off vacuum while feeding inert gas to the input of the system.
- Add activator solution (ascorbic acid), then purge the tube with inert gas for a few seconds and close it.
- Vortex the solution.
- Allow the mixture to stand at room temperature for 8–16 h.
- Use dialysis or size-exclusion chromatography to isolate the dye-protein conjugate.
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BDP 650/665 is a red-emitting borondipyrromethene dye. This azide derivative can be conjugated with alkynes and cycloalkynes.
Show pricing
| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| 18430 | 1 mg | $125 | in stock | |
| 28430 | 5 mg | $260 | in stock | |
| 38430 | 10 mg | $325 | in stock | |
| 48430 | 25 mg |
$510
|
in stock | |
| 58430 | 50 mg |
$895
|
in stock | |
| 68430 | 100 mg | please inquire | in stock |
BDP® FL alkyne
Borondipyrromethene dye alkyne for click chemistry. Bright and photostable dye for FAM channel.
Show pricing
| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| A14B0 | 1 mg | $125 | in stock | |
| B14B0 | 5 mg | $260 | in stock | |
| C14B0 | 10 mg | $325 | in stock | |
| D14B0 | 25 mg |
$510
|
in stock | |
| E14B0 | 50 mg |
$895
|
in stock | |
| F14B0 | 100 mg |
$1490
|
in stock |
BDP® FL azide
BDP FL is a bright and photostable borondipyrromethene dye for the fluorescein channel. This is a dye azide for сlick сhemistry.
Show pricing
| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| 11430 | 1 mg | $125 | in stock | |
| 21430 | 5 mg | $260 | in stock | |
| 31430 | 10 mg | $325 | in stock | |
| 41430 | 25 mg |
$510
|
in stock | |
| 51430 | 50 mg |
$895
|
in stock | |
| 61430 | 100 mg |
$1490
|
in stock |
BDP® R6G alkyne
Terminal alkyne derivative of BDP R6G dye for сlick chemistry. BDP R6G is a borondipyrromethene dye whose absorption and emission spectra are similar to R6G (rhodamine 6G).
Show pricing
| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| A44B0 | 1 mg | $125 | in stock | |
| B44B0 | 5 mg | $260 | in stock | |
| C44B0 | 10 mg | $325 | in stock | |
| D44B0 | 25 mg |
$510
|
in stock | |
| E44B0 | 50 mg |
$895
|
in stock | |
| F44B0 | 100 mg |
$1490
|
in stock |
BDP® R6G azide
BDP R6G is a high performance borondipyrromethene fluorophore which is tuned to match excitation and emission channels of R6G dye.
Show pricing
| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| 1476-1mg | 1 mg | $125 | in stock | |
| 1476-5mg | 5 mg | $260 | in stock | |
| 1476-10mg | 10 mg | $325 | in stock | |
| 1476-25mg | 25 mg |
$510
|
in stock | |
| 1476-50mg | 50 mg |
$895
|
in stock |
BDP® TMR alkyne
Borondipyrromethene dye for TAMRA channel, with alkyne group for copper-catalyzed click chemistry.
Show pricing
| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| A24B0 | 1 mg | $125 | in stock | |
| B24B0 | 5 mg | $260 | in stock | |
| C24B0 | 10 mg | $325 | in stock | |
| D24B0 | 25 mg |
$510
|
in stock | |
| E24B0 | 50 mg |
$895
|
5 days | |
| F24B0 | 100 mg |
$1490
|
in stock |
BDP® TMR azide
Borondipyrromethene dye with azido group. Spectral properties are similar to TAMRA dye. Due to long fluorescence lifetime, BDP TMR is especially useful for fluorescence polarization measurements.
Show pricing
| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| 12430 | 1 mg | $125 | in stock | |
| 22430 | 5 mg | $260 | in stock | |
| 32430 | 10 mg | $325 | in stock | |
| 42430 | 25 mg |
$410
|
in stock | |
| 52430 | 50 mg |
$895
|
in stock | |
| 62430 | 100 mg |
$1490
|
in stock |
BDP® TR alkyne
BDP TR is a fluorophore for ROX channel. This borondipyrromethene dye is very bright, and resistant to oxidation.
Show pricing
| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| A34B0 | 1 mg | $125 | in stock | |
| B34B0 | 5 mg | $260 | in stock | |
| C34B0 | 10 mg | $325 | in stock | |
| D34B0 | 25 mg |
$510
|
in stock | |
| E34B0 | 50 mg |
$895
|
in stock | |
| F34B0 | 100 mg |
$1490
|
in stock |
BDP® TR azide
BDP TR is a red-emitting fluorophore for the ROX channel. This is an azide for copper-catalyzed and copper-free сlick chemistry conjugation.
Show pricing
| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| 13430 | 1 mg | $125 | in stock | |
| 23430 | 5 mg | $260 | in stock | |
| 33430 | 10 mg | $325 | in stock | |
| 43430 | 25 mg |
$510
|
in stock | |
| 53430 | 50 mg |
$895
|
in stock | |
| 63430 | 100 mg |
$1490
|
in stock |
Biotin-PEG2-alkyne
Biotin alkyne is a reagent for click chemistry labeling with biotin, an affinity probe to streptavidin.
Show pricing
| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| 2546-50mg | 50 mg | $125 | in stock | |
| 2546-100mg | 100 mg | $185 | in stock | |
| 2546-1g | 1 g |
$990
|
in stock |
Biotin-PEG4-alkyne
Biotin alkyne is a reagent for click chemistry labeling with biotin, an affinity probe to streptavidin.
Show pricing
| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| 2615-50mg | 50 mg | $125 | in stock | |
| 2615-100mg | 100 mg | $185 | in stock | |
| 2615-1g | 1 g |
$990
|
in stock |
Copper(II)-THPTA catalytic buffer, 1.5x
Ready-to-use catalytic buffer containing сopper(II) and water-soluble THPTA ligand. It is suitable for click chemistry modification of proteins.
Show pricing
| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| B5150 | 1 mL | $30 | in stock | |
| K5150 | 10 mL | $120 | in stock | |
| S5150 | 50 mL |
$490
|
in stock |
Cyanine3.5 azide
Cyanine3.5 azide for biomolecule labeling through click chemistry.
Show pricing
| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| 12030 | 100 uL, 10 mM/DMSO | – | in stock | |
| 32030 | 500 uL, 10 mM/DMSO | $199 | in stock | |
| 42030 | 1 mL, 10 mM/DMSO |
$495
|
in stock | |
| A2030 | 1 mg | – | in stock | |
| B2030 | 5 mg | $199 | in stock | |
| C2030 | 10 mg | $297 | in stock | |
| D2030 | 25 mg |
$495
|
in stock | |
| E2030 | 50 mg |
$895
|
in stock | |
| F2030 | 100 mg |
$1490
|
in stock |
Cyanine3 alkyne
Cyanine3 alkyne is a fluorescent dye alkyne for сlick сhemistry.
Show pricing
| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| A10B0 | 1 mg | $125 | in stock | |
| B10B0 | 5 mg | $260 | in stock | |
| C10B0 | 10 mg | $325 | in stock | |
| D10B0 | 25 mg |
$510
|
in stock | |
| E10B0 | 50 mg |
$895
|
in stock | |
| F10B0 | 100 mg |
$1490
|
in stock |
Cyanine3 azide
Azide derivative of Cyanine3 fluorescent dye for сlick сhemistry.
Show pricing
| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| 11030 | 100 uL, 10 mM/DMSO | – | 20 days | |
| 31030 | 500 uL, 10 mM/DMSO | $199 | in stock | |
| 41030 | 1 mL, 10 mM/DMSO |
$495
|
in stock | |
| A1030 | 1 mg | – | in stock | |
| B1030 | 5 mg | $199 | in stock | |
| C1030 | 10 mg | $297 | in stock | |
| D1030 | 25 mg |
$495
|
in stock | |
| E1030 | 50 mg |
$895
|
in stock | |
| F1030 | 100 mg |
$1490
|
in stock |
Cyanine3B azide
Azide derivative of Cyanine3B fluorescent dye for сlick сhemistry.
Show pricing
| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| 19330 | 1 mg | $140 | in stock | |
| 29330 | 5 mg | $340 | in stock | |
| 49330 | 25 mg |
$990
|
in stock | |
| 59330 | 50 mg |
$1690
|
in stock | |
| 69330 | 100 mg |
$3100
|
in stock |
Cyanine5.5 alkyne
Cyanine5.5 alkyne is a NIR (near infrared) dye azide for copper-catalyzed сlick сhemistry.
Show pricing
| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| A70B0 | 1 mg | $125 | in stock | |
| B70B0 | 5 mg | $260 | in stock | |
| C70B0 | 10 mg | $325 | in stock | |
| D70B0 | 25 mg |
$510
|
in stock | |
| E70B0 | 50 mg |
$895
|
in stock | |
| F70B0 | 100 mg |
$1490
|
in stock |
Cyanine5.5 azide
Far red / near infrared fluorescent Cyanine5.5 dye derivative for click chemistry.
Show pricing
| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| 14030 | 100 uL, 10 mM/DMSO | – | in stock | |
| 34030 | 500 uL, 10 mM/DMSO | $199 | in stock | |
| 44030 | 1 mL, 10 mM/DMSO |
$495
|
in stock | |
| A4030 | 1 mg | – | in stock | |
| B4030 | 5 mg | $199 | in stock | |
| C4030 | 10 mg | $297 | in stock | |
| D4030 | 25 mg |
$495
|
in stock | |
| E4030 | 50 mg |
$895
|
in stock | |
| F4030 | 100 mg |
$1490
|
in stock |
Cyanine5 alkyne
Cyanine5 alkyne is an alkyne dye for click chemistry labeling of biomolecules.
Show pricing
| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| A30B0 | 1 mg | $125 | in stock | |
| B30B0 | 5 mg | $260 | in stock | |
| C30B0 | 10 mg | $325 | in stock | |
| D30B0 | 25 mg |
$510
|
in stock | |
| E30B0 | 50 mg |
$895
|
in stock | |
| F30B0 | 100 mg |
$1490
|
in stock |
Cyanine5 azide
Cyanine5 azide is a reagent for click chemistry labeling with Cyanine5, a popular fluorescent dye.
Show pricing
| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| 13030 | 100 uL, 10 mM/DMSO | – | in stock | |
| 33030 | 500 uL, 10 mM/DMSO | $199 | in stock | |
| 43030 | 1 mL, 10 mM/DMSO |
$495
|
in stock | |
| A3030 | 1 mg | – | in stock | |
| B3030 | 5 mg | $199 | in stock | |
| C3030 | 10 mg | $297 | in stock | |
| D3030 | 25 mg |
$495
|
in stock | |
| E3030 | 50 mg |
$895
|
in stock | |
| F3030 | 100 mg |
$1490
|
in stock |
Cyanine7.5 alkyne
Reactive near infrared (NIR) dye for click chemistry containing a terminal alkyne group.
Show pricing
| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| A60B0 | 1 mg | $125 | in stock | |
| B60B0 | 5 mg | $260 | in stock | |
| C60B0 | 10 mg | $325 | in stock | |
| D60B0 | 25 mg |
$510
|
in stock | |
| E60B0 | 50 mg |
$895
|
in stock | |
| F60B0 | 100 mg |
$1490
|
in stock |
Cyanine7.5 azide
Long-wavelength NIR fluorescent dye azide for click chemistry.
Show pricing
| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| 16030 | 100 uL, 10 mM/DMSO | – | in stock | |
| 36030 | 500 uL, 10 mM/DMSO | $199 | in stock | |
| 46030 | 1 mL, 10 mM/DMSO |
$495
|
in stock | |
| A6030 | 1 mg | – | in stock | |
| B6030 | 5 mg | $199 | in stock | |
| C6030 | 10 mg | $297 | in stock | |
| D6030 | 25 mg |
$495
|
in stock | |
| E6030 | 50 mg |
$895
|
in stock | |
| F6030 | 100 mg |
$1490
|
in stock |
Cyanine7 alkyne
Cyanine7 alkyne is a near infrared (NIR) dye alkyne for click chemistry.
Show pricing
| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| A50B0 | 1 mg | $125 | in stock | |
| B50B0 | 5 mg | $260 | in stock | |
| C50B0 | 10 mg | $325 | in stock | |
| D50B0 | 25 mg |
$510
|
in stock | |
| E50B0 | 50 mg |
$895
|
in stock | |
| F50B0 | 100 mg |
$1490
|
in stock |
Cyanine7 azide
Near-infrared (NIR) fluorescent dye for click chemistry labeling.
Show pricing
| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| 15030 | 100 uL, 10 mM/DMSO | – | in stock | |
| 35030 | 500 uL, 10 mM/DMSO | $199 | in stock | |
| 45030 | 1 mL, 10 mM/DMSO |
$495
|
in stock | |
| A5030 | 1 mg | – | in stock | |
| B5030 | 5 mg | $199 | in stock | |
| C5030 | 10 mg | $297 | in stock | |
| D5030 | 25 mg |
$495
|
in stock | |
| E5030 | 50 mg |
$895
|
in stock |
DusQ 3 azide
DusQ 3 dark quencher with azido group for the conjugation with alkyne-containing molecules
Show pricing
| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| 23D30 | 5 mg | $225 | in stock | |
| 43D30 | 25 mg | $390 | in stock | |
| 63D30 | 100 mg |
$1090
|
in stock |
FAM alkyne, 5-isomer
FAM alkyne, 5-isomer - an alkyne derivative of fluorescein dye for click chemistry.
Show pricing
| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| A41B0 | 1 mg | – | in stock | |
| B41B0 | 5 mg | $100 | in stock | |
| C41B0 | 10 mg | $150 | in stock | |
| D41B0 | 25 mg | $295 | in stock | |
| E41B0 | 50 mg |
$450
|
in stock | |
| F41B0 | 100 mg |
$780
|
in stock |
FAM alkyne, 6-isomer
Fluorescein dye alkyne for click chemistry conjugation, pure 6-isomer.
Show pricing
| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| A51B0 | 1 mg | – | in stock | |
| B51B0 | 5 mg | $100 | in stock | |
| C51B0 | 10 mg | $150 | in stock | |
| D51B0 | 25 mg | $295 | in stock | |
| E51B0 | 50 mg |
$450
|
in stock | |
| F51B0 | 100 mg |
$780
|
in stock |
FAM azide, 5-isomer
FAM (fluorescein) azide for сlick chemistry labeling, pure 5-isomer.
Show pricing
| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| 14130 | 100 uL, 10 mM/DMSO | $69 | in stock | |
| 34130 | 500 uL, 10 mM/DMSO | $97 | in stock | |
| 44130 | 1 mL, 10 mM/DMSO | $139 | in stock | |
| A4130 | 1 mg | $69 | in stock | |
| B4130 | 5 mg | $97 | in stock | |
| C4130 | 10 mg | $139 | in stock | |
| D4130 | 25 mg | $285 | in stock | |
| E4130 | 50 mg |
$445
|
in stock | |
| F4130 | 100 mg |
$765
|
in stock |
FAM azide, 6-isomer
FAM (fluorescein) azide, 6-isomer is a commonly used fluorescent dye azide for сlick сhemistry.
Show pricing
| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| 15130 | 100 uL, 10 mM/DMSO | $69 | in stock | |
| 35130 | 500 uL, 10 mM/DMSO | $97 | in stock | |
| 45130 | 1 mL, 10 mM/DMSO | $139 | in stock | |
| A5130 | 1 mg | $69 | in stock | |
| B5130 | 5 mg | $97 | in stock | |
| C5130 | 10 mg | $139 | in stock | |
| D5130 | 25 mg | $285 | in stock | |
| E5130 | 50 mg |
$445
|
in stock | |
| F5130 | 100 mg |
$765
|
in stock |
HEX azide, 6-isomer
Azide of green-yellow emitting HEX dye for conjugation with oligonucleotides via [3+2]-dipolar cycloaddition.
Show pricing
| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| AB230 | 1 mg | $110 | in stock | |
| BB230 | 5 mg | $165 | in stock | |
| CB230 | 10 mg | $210 | in stock | |
| DB230 | 25 mg | $285 | in stock | |
| EB230 | 50 mg |
$495
|
in stock | |
| FB230 | 100 mg |
$880
|
in stock |
Hexynoic acid NHS ester
Hexynoic acid NHS ester for the labeling of biomolecules with alkyne group for copper-catalyzed click chemistry.
Show pricing
| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| 41720 | 25 mg | $95 | in stock | |
| 51720 | 50 mg | $180 | in stock | |
| 61720 | 100 mg | $290 | in stock | |
| 91720 | 1 g | please inquire | in stock |
Hexynoic acid STP ester
Alkyne activated ester for the modification of amine groups. STP ester group is an excellent alternative to NHS ester functionality.
Show pricing
| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| 569-25mg | 25 mg | $95 | in stock | |
| 569-100mg | 100 mg | $185 | in stock | |
| 569-500mg | 500 mg |
$850
|
in stock |
JOE alkyne, 6-isomer
JOE dye alkyne derivative for copper-catalyzed click chemistry reaction with azides. JOE dye is widely used for nucleic acid labeling.
Show pricing
| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| A21B0 | 1 mg | $110 | in stock | |
| B21B0 | 5 mg | $210 | in stock | |
| C21B0 | 10 mg | $310 | in stock | |
| D21B0 | 25 mg |
$410
|
in stock | |
| E21B0 | 50 mg |
$695
|
in stock | |
| F21B0 | 100 mg |
$1190
|
in stock |
JOE azide, 5-isomer
JOE is a chlorinated fluorescein dye which is often used for HEX channel for oligonucleotides. It is less hydrophobic than HEX. This is an azide derivative for сlick chemistry
Show pricing
| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| A1130 | 1 mg | $110 | in stock | |
| B1130 | 5 mg | $210 | in stock | |
| C1130 | 10 mg | $310 | in stock | |
| D1130 | 25 mg |
$410
|
in stock | |
| E1130 | 50 mg |
$695
|
in stock | |
| F1130 | 100 mg |
$1190
|
in stock |
Pentynoic acid STP ester
An activated ester for the introduction of alkyne into peptides/proteins and click reaction.
Show pricing
| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| 30720 | 10 mg | $110 | in stock | |
| 40720 | 25 mg | $210 | in stock | |
| 50720 | 50 mg |
$410
|
in stock | |
| 60720 | 100 mg |
$595
|
10 days |
Pyrene azide 1
Reagent for fluorescent labeling with pyrene polycyclic aromatic hydrocarbon via click chemistry.
Show pricing
| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| A1530 | 1 mg | $110 | 5 days | |
| B1530 | 5 mg | $210 | in stock | |
| C1530 | 10 mg | $310 | in stock | |
| D1530 | 25 mg |
$410
|
in stock | |
| E1530 | 50 mg |
$695
|
in stock |
Pyrene azide 2
Pyrene azide with longer triethyleneglycol (PEG3) linker for click chemistry.
Show pricing
| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| A2530 | 1 mg | $110 | in stock | |
| B2530 | 5 mg | $210 | in stock | |
| C2530 | 10 mg | $310 | in stock | |
| D2530 | 25 mg |
$410
|
in stock | |
| E2530 | 50 mg |
$695
|
in stock |
R110 azide, 6-isomer
Rhodamine 110 (R110) azide for click chemistry, pure 6-isomer.
Show pricing
| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| 15230 | 100 uL, 10 mM/DMSO | $160 | in stock | |
| 35230 | 500 uL, 10 mM/DMSO |
$420
|
in stock | |
| 45230 | 1 mL, 10 mM/DMSO |
$595
|
in stock | |
| A5230 | 1 mg | $115 | in stock | |
| D5230 | 25 mg |
$510
|
in stock | |
| E5230 | 50 mg |
$895
|
in stock | |
| F5230 | 100 mg | please inquire | in stock |
R6G alkyne, 6-isomer
R6G (rhodamine 6G) terminal alkyne for copper-catalyzed click chemistry reaction with azides. Pure 6-isomer of the dye.
Show pricing
| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| A52B0 | 1 mg | $110 | in stock | |
| B52B0 | 5 mg | $210 | in stock | |
| C52B0 | 10 mg | $310 | in stock | |
| D52B0 | 25 mg |
$410
|
in stock | |
| E52B0 | 50 mg |
$695
|
in stock | |
| F52B0 | 100 mg |
$1190
|
in stock |
R6G azide, 5-isomer
Rhodamine 6G is a xanthene dye that has been used for DNA sequencing and qPCR. This azide derivative is used for the attachment of the dye to DNA and other molecules by means of click chemistry.
Show pricing
| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| A4430 | 1 mg | $110 | in stock | |
| B4430 | 5 mg | $210 | in stock | |
| C4430 | 10 mg | $310 | in stock | |
| D4430 | 25 mg |
$410
|
in stock | |
| E4430 | 50 mg |
$695
|
in stock |
ROX alkyne, 5-isomer
An alkyne derivative of bright red-emitting dye ROX (Rhodamine X, Rhodamine 101) for copper-catalyzed click chemistry bioconjugation. Pure 5-isomer.
Show pricing
| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| A12B0 | 1 mg | $110 | in stock | |
| B12B0 | 5 mg | $165 | in stock | |
| C12B0 | 10 mg | $210 | in stock | |
| D12B0 | 25 mg | $285 | in stock | |
| E12B0 | 50 mg |
$495
|
in stock | |
| F12B0 | 100 mg |
$1190
|
in stock |
ROX alkyne, 6-isomer
An alkyne derivative of bright red-emitting dye ROX (Rhodamine X, Rhodamine 101) for copper-catalyzed click chemistry bioconjugation. Pure 6-isomer.
Show pricing
| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| A22B0 | 1 mg | $110 | in stock | |
| B22B0 | 5 mg | $165 | in stock | |
| C22B0 | 10 mg | $210 | in stock | |
| D22B0 | 25 mg | $285 | in stock | |
| E22B0 | 50 mg |
$495
|
in stock | |
| F22B0 | 100 mg |
$880
|
in stock |
ROX azide, 5-isomer
Azide derivative of ROX (Rhodamine X, Rhodamine 101) dye for biomolecule labeling via click chemistry. Pure 5-isomer.
Show pricing
| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| A1230 | 1 mg | $110 | in stock | |
| B1230 | 5 mg | $165 | in stock | |
| C1230 | 10 mg | $210 | in stock | |
| D1230 | 25 mg | $299 | in stock | |
| E1230 | 50 mg |
$495
|
in stock |
ROX azide, 6-isomer
Azide derivative of ROX (Rhodamine X, Rhodamine 101) dye for biomolecule labeling via click chemistry. Pure 6-isomer.
Show pricing
| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| A2230 | 1 mg | $110 | in stock | |
| B2230 | 5 mg | $165 | in stock | |
| C2230 | 10 mg | $210 | in stock | |
| D2230 | 25 mg | $299 | in stock | |
| E2230 | 50 mg |
$495
|
in stock |
SIMA azide, 6-isomer
Azide of green-yellow emitting dye SIMA for conjugation with oligonucleotides via [3+2]-dipolar cycloaddition.
Show pricing
| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| AE230 | 1 mg | $110 | in stock | |
| BE230 | 5 mg | $180 | in stock | |
| CE230 | 10 mg | $310 | in stock | |
| DE230 | 25 mg |
$410
|
in stock | |
| EE230 | 50 mg |
$695
|
in stock | |
| FE230 | 100 mg |
$1190
|
in stock |
sulfo-Cyanine3.5 alkyne
Alkyne derivative of water-soluble sulfo-Cyanine3.5 dye for copper-catalyzed click chemistry.
Show pricing
| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| A23B0 | 1 mg | $125 | in stock | |
| B23B0 | 5 mg | $260 | in stock | |
| C23B0 | 10 mg | $325 | in stock | |
| D23B0 | 25 mg |
$510
|
in stock | |
| E23B0 | 50 mg |
$895
|
in stock | |
| F23B0 | 100 mg |
$1490
|
in stock |
sulfo-Cyanine3.5 azide
Azide derivative of water-soluble sulfo-Cyanine3.5 dye for bioconjugation via click chemistry.
Show pricing
| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| A2330 | 1 mg | $125 | in stock | |
| B2330 | 5 mg | $325 | in stock | |
| C2330 | 10 mg |
$470
|
in stock | |
| D2330 | 25 mg |
$850
|
in stock | |
| E2330 | 50 mg |
$1490
|
in stock | |
| F2330 | 100 mg |
$1990
|
in stock |
sulfo-Cyanine3 alkyne
A water-soluble dye alkyne for copper-catalyzed click chemistry. The fluorophore sulfo-Cyanine3 is a bright and photostable dye for the Cy3® channel.
Show pricing
| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| A13B0 | 1 mg | $125 | in stock | |
| B13B0 | 5 mg | $325 | in stock | |
| C13B0 | 10 mg |
$470
|
in stock | |
| D13B0 | 25 mg |
$850
|
in stock | |
| E13B0 | 50 mg |
$1490
|
in stock | |
| F13B0 | 100 mg |
$1990
|
in stock |
sulfo-Cyanine3 azide
Water-soluble sulfo-Cyanine3 dye azide for click chemistry labeling of sensitive molecules and intact biological objects.
Show pricing
| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| 1330-x05mg | 0.50 mg | – | in stock | |
| A1330 | 1 mg | $125 | in stock | |
| B1330 | 5 mg | $325 | in stock | |
| C1330 | 10 mg |
$470
|
in stock | |
| D1330 | 25 mg |
$790
|
in stock | |
| E1330 | 50 mg |
$1490
|
in stock | |
| F1330 | 100 mg |
$2590
|
in stock |
sulfo-Cyanine5.5 alkyne
Alkyne functionalized, water soluble far red/near infrared emitting fluorophore sulfo-Cyanine5.5.
Show pricing
| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| A73B0 | 1 mg | $110 | in stock | |
| B73B0 | 5 mg | $325 | in stock | |
| C73B0 | 10 mg |
$470
|
in stock | |
| D73B0 | 25 mg |
$850
|
in stock | |
| E73B0 | 50 mg |
$1490
|
in stock | |
| F73B0 | 100 mg |
$2590
|
in stock |
sulfo-Cyanine5.5 azide
sulfo-Cyanine5.5 azide is a derivative of water-soluble far-red emitting fluorescent cyanine dye. The azide group can be conjugated by either copper-catalyzed or copper-free click chemistry with alkynes and cycloalkynes.
Show pricing
| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| A7330 | 1 mg | $110 | in stock | |
| B7330 | 5 mg | $325 | in stock | |
| C7330 | 10 mg |
$470
|
in stock | |
| D7330 | 25 mg |
$850
|
in stock | |
| E7330 | 50 mg |
$1490
|
in stock | |
| F7330 | 100 mg |
$2590
|
in stock |
sulfo-Cyanine5 alkyne
sulfo-Cyanine5 is a water-soluble Cyanine5 dye alkyne for click chemistry.
Show pricing
| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| A33B0 | 1 mg | $125 | in stock | |
| B33B0 | 5 mg | $290 | in stock | |
| C33B0 | 10 mg |
$470
|
in stock | |
| D33B0 | 25 mg |
$850
|
in stock | |
| E33B0 | 50 mg |
$1490
|
in stock | |
| F33B0 | 100 mg |
$1990
|
in stock |
sulfo-Cyanine5 azide
Water soluble sulfo-Cyanine5 fluorescent dye azide for click chemistry.
Show pricing
| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| A3330 | 1 mg | $125 | in stock | |
| B3330 | 5 mg | $325 | in stock | |
| C3330 | 10 mg |
$470
|
in stock | |
| D3330 | 25 mg |
$790
|
in stock | |
| E3330 | 50 mg |
$1490
|
in stock | |
| F3330 | 100 mg |
$2590
|
in stock |
sulfo-Cyanine7.5 alkyne
sulfo-Cyanine7.5 is a near-infrared fluorophore similar to Indocyanine Green (ICG) but possesses higher fluorescence quantum yield. This is an alkyne for copper-catalyzed click chemistry.
Show pricing
| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| A63B0 | 1 mg | $125 | in stock | |
| B63B0 | 5 mg | $325 | in stock | |
| C63B0 | 10 mg |
$470
|
in stock | |
| D63B0 | 25 mg |
$850
|
in stock | |
| E63B0 | 50 mg |
$1490
|
in stock | |
| F63B0 | 100 mg |
$1990
|
in stock |
sulfo-Cyanine7.5 azide
sulfo-Cyanine7.5 is a very hydrophilic and water-soluble dye for the near-infrared region. The absorption and emission spectra of the dye are similar to Indocyanine Green (ICG), but sulfo-Cyanine7.5 has a much higher fluorescence quantum yield. The dye is a great choice for near-infrared in vivo imaging. This is an azide for click chemistry.
Show pricing
| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| A6330 | 1 mg | $125 | in stock | |
| B6330 | 5 mg | $325 | in stock | |
| C6330 | 10 mg |
$470
|
in stock | |
| D6330 | 25 mg |
$850
|
in stock | |
| E6330 | 50 mg |
$1490
|
in stock | |
| F6330 | 100 mg |
$1990
|
in stock |
sulfo-Cyanine7 alkyne
A sulfonated near-infrared dye alkyne for copper-catalyzed cycloaddition with azides.
Show pricing
| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| A53B0 | 1 mg | $125 | in stock | |
| B53B0 | 5 mg | $325 | in stock | |
| C53B0 | 10 mg |
$470
|
in stock | |
| D53B0 | 25 mg |
$850
|
in stock | |
| E53B0 | 50 mg |
$1490
|
in stock | |
| F53B0 | 100 mg |
$1990
|
in stock |
sulfo-Cyanine7 azide
Water-soluble NIR fluorescent dye azide for click chemistry.
Show pricing
| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| A5330 | 1 mg | $125 | in stock | |
| B5330 | 5 mg | $325 | in stock | |
| C5330 | 10 mg |
$470
|
in stock | |
| D5330 | 25 mg |
$850
|
in stock | |
| E5330 | 50 mg |
$1490
|
in stock | |
| F5330 | 100 mg |
$1990
|
in stock |
TAMRA alkyne, 5-isomer
Alkyne derivative of TAMRA dye, pure 5-isomer for сopper-catalyzed сlick chemistry.
Show pricing
| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| A71B0 | 1 mg | – | in stock | |
| B71B0 | 5 mg | $260 | in stock | |
| C71B0 | 10 mg | $325 | in stock | |
| D71B0 | 25 mg |
$410
|
in stock | |
| E71B0 | 50 mg |
$695
|
in stock | |
| F71B0 | 100 mg |
$890
|
in stock |
TAMRA alkyne, 6-isomer
Terminal alkyne for copper-catalyzed click chemistry. Tetramethylrhodamine (TAMRA) is a rhodamine dye which is popular in qPCR and other applications. TAMRA is a also a FRET acceptor for FAM.
Show pricing
| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| A81B0 | 1 mg | – | in stock | |
| B81B0 | 5 mg | $260 | in stock | |
| C81B0 | 10 mg | $325 | in stock | |
| D81B0 | 25 mg |
$410
|
in stock | |
| E81B0 | 50 mg |
$695
|
in stock |
TAMRA azide, 5-isomer
Azide derivative of TAMRA fluorescent dye for сlick chemistry.
Show pricing
| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| A7130 | 1 mg | $110 | in stock | |
| B7130 | 5 mg | $135 | 5 days | |
| C7130 | 10 mg | $210 | in stock | |
| D7130 | 25 mg | $390 | in stock | |
| E7130 | 50 mg |
$595
|
in stock | |
| F7130 | 100 mg |
$790
|
in stock |
TAMRA azide, 6-isomer
Pure 6-isomer of tetramethylrhodamine (TAMRA) dye, azide derivative for copper-catalyzed and copper-free click chemistry reactions with alkynes.
Show pricing
| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| A8130 | 1 mg | $110 | in stock | |
| B8130 | 5 mg | $135 | in stock | |
| C8130 | 10 mg | $210 | in stock | |
| D8130 | 25 mg | $390 | in stock | |
| E8130 | 50 mg |
$595
|
in stock | |
| F8130 | 100 mg |
$790
|
in stock |
TET azide, 6-isomer
TET is a green-fluorescent fluorescein derivate with spectral properties similar to R6G, JOE, and VIC, widely used for labeling PCR probes. This reagent is an azide for dye conjugation by click chemistry.
Show pricing
| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| 18230 | 1 mg | $110 | in stock | |
| 28230 | 5 mg | $165 | in stock | |
| 48230 | 25 mg | $285 | in stock | |
| 58230 | 50 mg |
$495
|
in stock | |
| 68230 | 100 mg |
$880
|
in stock |
TR azide, 5-isomer
Azide derivative of red fluorescent dye TR for сlick сhemistry conjugation. Pure 5-isomer.
Show pricing
| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| AY230 | 1 mg | $110 | in stock | |
| DY230 | 25 mg |
$410
|
in stock | |
| FY230 | 100 mg |
$1190
|
in stock |
VIC azide, 6-isomer
VIC is an asymmetric xanthene dye with spectral properties similar to HEX and JOE, widely used for labeling PCR probes. This derivative is an azide for dye conjugation by click chemistry.
Show pricing
| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| 1H230 | 1 mg | $110 | in stock | |
| 2H230 | 5 mg | $210 | in stock | |
| 4H230 | 25 mg |
$410
|
in stock | |
| 5H230 | 50 mg |
$695
|
in stock | |
| 6H230 | 100 mg |
$1190
|
in stock |
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