Cycloalkynes in Reactive groups
Strained cycloalkynes, like cyclooctynes, react quickly with azides in a reaction called SPAAC, strain-promoted alkyne-azide cycloaddition. The reaction does not require catalyst, it is very rapid and high yielding. The process is useful for the conjugation of different classes of molecules even in vivo.
There is a balance between reactivity and stability of cycloalkynes. Azodibenzocyclooctynes (DBCO, ADIBO) are cyclooctyne derivatives that are characterized by excellent reaction kinetics and very good stability.
AF 488 DBCO
Dibenzocyclooctyne (DBCO, ADIBO) containing the green fluorophore AF 488 for labeling azide-tagged biomolecules inside live cells, whole organisms, and inanimate samples. Pure 5-isomer.
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| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| 118F0 | 1 mg | $140 | in stock | |
| 218F0 | 5 mg |
$450
|
in stock | |
| 418F0 | 25 mg |
$1460
|
in stock | |
| 518F0 | 50 mg |
$1890
|
in stock | |
| 618F0 | 100 mg |
$2640
|
in stock |
AF 555 DBCO
Dibenzocyclooctyne (DBCO, ADIBO) containing the yellow fluorophore AF 555 for labeling azide-tagged biomolecules inside live cells, whole organisms, and inanimate samples.
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| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| 1K8F0 | 1 mg | $140 | in stock | |
| 2K8F0 | 5 mg |
$450
|
in stock | |
| 4K8F0 | 25 mg |
$1460
|
in stock | |
| 5K8F0 | 50 mg |
$1890
|
in stock | |
| 6K8F0 | 100 mg |
$2990
|
in stock |
AF 568 DBCO
Dibenzocyclooctyne (DBCO, ADIBO) containing the orange fluorophore AF 568 for cooper-free labeling azide-tagged biomolecules inside live cells, whole organisms, and inanimate samples.
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| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| 1158F0 | 1 mg | $140 | in stock | |
| 2158F0 | 5 mg |
$450
|
in stock | |
| 4158F0 | 25 mg |
$1460
|
in stock | |
| 5158F0 | 50 mg |
$1890
|
in stock | |
| 6158F0 | 100 mg |
$2990
|
in stock |
AF 647 DBCO
Dibenzocyclooctyne (DBCO, ADIBO) derivative of the far red fluorophore AF 647 for labeling azide-tagged biomolecules inside live cells, whole organisms, and inanimate samples.
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| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| 1G8F0 | 1 mg | $140 | in stock | |
| 2G8F0 | 5 mg |
$450
|
in stock | |
| 4G8F0 | 25 mg |
$1460
|
in stock | |
| 5G8F0 | 50 mg |
$1890
|
in stock | |
| 6G8F0 | 100 mg |
$2990
|
in stock |
BDP® 558/568 DBCO
BDP 558/568 DBCO is a bright and photostable dye with emission in the yellow spectrum range. It contains a cyclooctyne substituting group (i.e. DBCO), which can react with various azides in Click Chemistry reactions.
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| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| 174F0 | 1 mg | $125 | in stock | |
| 274F0 | 5 mg | $260 | in stock | |
| 374F0 | 10 mg | $325 | in stock | |
| 474F0 | 25 mg |
$510
|
in stock | |
| 574F0 | 50 mg |
$895
|
in stock | |
| 674F0 | 100 mg |
$1490
|
in stock |
BDP® 581/591 DBCO
BDP 581/591 is a borondipyrromethene dye that can be used not only as a fluorescent dye, but also as a ROS probe. It can be conjugated with azides using copper-free click chemistry.
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| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| A64F0 | 1 mg | $125 | in stock | |
| B64F0 | 5 mg | $260 | in stock | |
| C64F0 | 10 mg | $325 | in stock | |
| D64F0 | 25 mg |
$510
|
in stock | |
| E64F0 | 50 mg |
$895
|
in stock | |
| F64F0 | 100 mg |
$1490
|
in stock |
BDP® 650/665 DBCO
This red-fluorescent dye contains a substituting group for copper-free click chemistry.
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| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| AE4F0 | 1 mg | $125 | in stock | |
| BE4F0 | 5 mg | $260 | in stock | |
| CE4F0 | 10 mg | $325 | in stock | |
| DE4F0 | 25 mg |
$510
|
in stock | |
| EE4F0 | 50 mg |
$895
|
in stock | |
| FE4F0 | 100 mg |
$1490
|
in stock |
BDP® FL DBCO
BDP FL DBCO is a dye cyclooctyne for copper-free click chemistry reactions with azides. Its absorption and emission wavelengths correspond to those of fluorescein (FAM), but BDP FL is significantly more photostable.
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| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| A14F0 | 1 mg | $125 | in stock | |
| B14F0 | 5 mg | $260 | in stock | |
| C14F0 | 10 mg | $325 | in stock | |
| D14F0 | 25 mg |
$510
|
in stock | |
| E14F0 | 50 mg |
$895
|
in stock | |
| F14F0 | 100 mg |
$1490
|
in stock |
BDP® R6G DBCO
A derivative of BDP R6G dye with azodibenzocyclooctyne (DBCO or ADIBO) for copper-free click chemistry conjugation with azides.
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| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| A44F0 | 1 mg | $125 | in stock | |
| B44F0 | 5 mg | $260 | in stock | |
| C44F0 | 10 mg | $325 | in stock | |
| D44F0 | 25 mg |
$510
|
in stock | |
| E44F0 | 50 mg |
$895
|
in stock | |
| F44F0 | 100 mg |
$1490
|
in stock |
BDP® TMR DBCO
This yellow-orange-fluorescent boron dipyrromethene dye contains a DBCO substituting group for participation in click chemistry reactions.
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| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| 124F0 | 1 mg | $125 | in stock | |
| 224F0 | 5 mg | $260 | in stock | |
| 424F0 | 25 mg |
$510
|
in stock | |
| 524F0 | 50 mg |
$895
|
in stock | |
| 624F0 | 100 mg |
$1490
|
in stock |
BDP® TR DBCO
A dye with a dibenzocyclooctyne substituting group for the ROX channel.
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| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| 1D4F0 | 1 mg | $125 | in stock | |
| 2D4F0 | 5 mg | $260 | in stock | |
| 4D4F0 | 25 mg |
$510
|
in stock | |
| 5D4F0 | 50 mg |
$895
|
in stock | |
| 6D4F0 | 100 mg |
$1490
|
in stock |
Cyanine3 DBCO
Cyanine3 dibenzocyclooctyne (DBCO, or ADIBO) is a cycloalkyne dye derivative for copper-free click chemistry.
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| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| A10F0 | 1 mg | $125 | in stock | |
| B10F0 | 5 mg | $260 | in stock | |
| C10F0 | 10 mg | $325 | in stock | |
| D10F0 | 25 mg |
$510
|
in stock | |
| E10F0 | 50 mg |
$895
|
in stock | |
| F10F0 | 100 mg |
$1490
|
in stock |
Cyanine3-PEG4-BCN (exo)
Cyanine3-PEG4-BCN is an ethylene glycol separated linker for the azido-modified molecules for copper-free click conjugation.
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| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| NO items of this product available in stock but you can submit request for bulk. | ||||
Cyanine3.5 DBCO
Cyclooctyne derivative of Cyanine3.5 dye, which easily reacts with various azides resulting in stable conjugates.
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| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| A20F0 | 1 mg | $125 | in stock | |
| B20F0 | 5 mg | $260 | in stock | |
| C20F0 | 10 mg | $325 | in stock | |
| D20F0 | 25 mg |
$510
|
in stock | |
| E20F0 | 50 mg |
$895
|
in stock | |
| F20F0 | 100 mg |
$1490
|
in stock |
Cyanine3B DBCO
Dibenzocyclooctyne (DBCO, ADIBO) containing Cyanine3B fluorophore for labeling azide-tagged biomolecules inside live cells, whole organisms, and inanimate samples.
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| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| 193F0 | 1 mg | $369 | in stock | |
| 293F0 | 5 mg |
$727
|
in stock | |
| 493F0 | 25 mg |
$1950
|
in stock |
Cyanine5 DBCO
Cyanine5 dye with dibenzocyclooctyne (DBCO) functional group for copper-free click chemistry.
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| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| A30F0 | 1 mg | $125 | in stock | |
| B30F0 | 5 mg | $260 | in stock | |
| C30F0 | 10 mg | $325 | in stock | |
| D30F0 | 25 mg |
$510
|
in stock | |
| E30F0 | 50 mg |
$895
|
in stock | |
| F30F0 | 100 mg |
$1490
|
in stock |
Cyanine5.5 DBCO
Cyanine5.5 is a far-red / NIR emitting dye that is useful for bioimaging studies. Cyanine5.5 DBCO is a derivative of the dye with a cycloalkyne moiety for copper-free click chemistry.
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| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| A70F0 | 1 mg | $125 | in stock | |
| B70F0 | 5 mg | $260 | in stock | |
| C70F0 | 10 mg | $325 | in stock | |
| D70F0 | 25 mg |
$510
|
in stock | |
| E70F0 | 50 mg |
$895
|
in stock | |
| F70F0 | 100 mg |
$1490
|
in stock |
Cyanine7 DBCO
NIR fluorescent dye functionalized with cyclooctyne moiety for copper free click chemistry conjugation with azides.
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| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| A50F0 | 1 mg | $125 | in stock | |
| B50F0 | 5 mg | $260 | in stock | |
| C50F0 | 10 mg | $325 | in stock | |
| D50F0 | 25 mg |
$510
|
in stock | |
| E50F0 | 50 mg |
$895
|
in stock | |
| F50F0 | 100 mg |
$1490
|
in stock |
DBCO-amine trifluoroacetate
Bifunctional linker containing dibenzocyclooctyne (DBCO, ADIBO) for strain-promoted copper-free click reaction (SPAAC) and free amine for the coupling with various electrophilic compounds like activated esters and epoxides.
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| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| 1280-100mg | 100 mg | $218 | in stock | |
| 1280-500mg | 500 mg |
$678
|
in stock | |
| 1280-1g | 1 g |
$1200
$1018
|
in stock |
DBCO-maleimide
Bifunctional linker containing a thiol-reactive maleimide group and an azide-reactive dibenzocyclooctyne moiety.
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| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| 4448-100mg | 100 mg | $319 | in stock | |
| 4448-500mg | 500 mg |
$1028
|
in stock |
DBCO-NHS ester
Azodibenzocyclooctyne (DBCO, ADIBO) reagent for strain-promoted copper-free click chemistry (SPAAC). The reagent contains an NHS ester function for the attachment of the cyclooctyne to various molecules.
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| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| 34720 | 10 mg | $80 | in stock | |
| 44720 | 25 mg | $110 | in stock | |
| 54720 | 50 mg | $135 | in stock | |
| 64720 | 100 mg |
$210
$178
|
in stock | |
| 94720 | 1 g |
$1000
$970
|
in stock | |
| K4720 | 5 g |
$3570
$2990
|
in stock |
DBCO-PEG6-NHS ester
A heterobifunctional linker with DBCO and NHS ester function groups flanking PEG6 (hexaethylene glycol).
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| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| 3664-50mg | 50 mg | $247 | in stock | |
| 3664-100mg | 100 mg |
$449
|
in stock | |
| 3664-1g | 1 g |
$3490
|
5 days |
DBCO-STP ester
Activated ester for modification of proteins/antibodies/peptides followed by introduction into copper-free click chemistry reaction.
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| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| 2584-10mg | 10 mg | $90 | in stock | |
| 2584-25mg | 25 mg | $180 | in stock | |
| 2584-100mg | 100 mg |
$450
|
in stock | |
| 2584-500mg | 500 mg |
$1700
|
5 days | |
| 2584-1g | 1 g |
$3000
|
in stock | |
| 2584-5g | 5 g | please inquire | in stock |
endo-BCN CE-phosphoramidite
BCN-containing phosphoramidite for the synthesis of oligonucleotides and their labeling using copper-free click reactions.
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| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| 3005-100mg | 100 mg | $390 | in stock | |
| 3005-250mg | 250 mg |
$850
|
in stock | |
| 3005-1g | 1 g |
$2380
|
in stock |
exo-BCN CE-phosphoramidite
BCN-containing phosphoramidite for the synthesis of oligonucleotides and their labeling using copper-free click reactions.
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| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
|
4396-250mg
/ 8 mL septum
|
250 mg |
$790
|
7 days | |
|
4396-1g
/ 8 mL septum
|
1 g |
$2340
|
21 days | |
|
4396-5g
/ 8 mL septum
|
5 g | please inquire | 21 days |
Exo-BCN-PNP
BCN-PNP carbonate is a tool to introduce BCN moety via carbamate linkage with primary amino groups of substrate.
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| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| 4043-100mg | 100 mg | $280 | in stock | |
| 4043-500mg | 500 mg |
$990
|
in stock |
FAM DBCO, 6-isomer
Cyclooctyne derivative of fluorescein (FAM) for copper-free click chemistry reaction with azides. Pure 6-isomer of fluorescein.
Show pricing
| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| 151F0 | 1 mg | $110 | in stock | |
| 251F0 | 5 mg | $160 | in stock | |
| 451F0 | 25 mg | $260 | in stock | |
| 551F0 | 50 mg | $370 | in stock | |
| 651F0 | 100 mg |
$525
|
in stock |
ROX DBCO, 5-isomer
ROX (rhodamine X) is a bright rhodamine dye. This is a DBCO (dibenzocyclooctyne) derivative that has high reactivity against azides.
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| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| 112F0 | 1 mg | $110 | in stock | |
| 212F0 | 5 mg | $210 | in stock | |
| 412F0 | 25 mg |
$410
|
in stock | |
| 512F0 | 50 mg |
$695
|
in stock | |
| 612F0 | 100 mg |
$1190
|
in stock |
sulfo-Cyanine3 DBCO
sulfo-Cyanine3 DBCO is a cycloalkyne derivative of water-soluble fluorophore sulfo-Cyanine3 for copper-free click chemistry.
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| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| 113F0 | 1 mg | $125 | in stock | |
| 213F0 | 5 mg | $325 | in stock | |
| 413F0 | 25 mg |
$850
|
in stock | |
| 513F0 | 50 mg |
$1490
|
in stock | |
| 613F0 | 100 mg |
$1990
|
in stock |
sulfo-Cyanine5 DBCO
Water-soluble cycloalkyne for copper-free click chemistry reaction with azides. A derivative of sulfo-Cyanine5.
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| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| 133F0 | 1 mg | $125 | in stock | |
| 233F0 | 5 mg | $325 | in stock | |
| 433F0 | 25 mg |
$850
|
in stock | |
| 533F0 | 50 mg |
$1490
|
in stock | |
| 633F0 | 100 mg |
$1990
|
in stock |
sulfo-Cyanine5.5 DBCO
Sulfo-Cyanine5.5 DBCO is a far-red, water-soluble reagent for copper-free click reaction with azides.
Show pricing
| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| 173F0 | 1 mg | $125 | in stock | |
| 273F0 | 5 mg | $325 | in stock | |
| 473F0 | 25 mg |
$850
|
in stock | |
| 573F0 | 50 mg |
$1490
|
in stock | |
| 673F0 | 100 mg |
$1990
|
in stock |
sulfo-Cyanine7 DBCO
Dibenzocyclooctyne (DBCO, or ADIBO) conjugated with sulfo-Cyanine7, a water-soluble near-IR dye for labeling azide-containing biomolecules inside living cells, whole organisms, and inanimate samples.
Show pricing
| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| 153F0 | 1 mg | $125 | in stock | |
| 253F0 | 5 mg | $325 | in stock | |
| 453F0 | 25 mg |
$850
|
in stock | |
| 553F0 | 50 mg |
$1490
|
in stock | |
| 653F0 | 100 mg |
$1990
|
in stock |
TAMRA DBCO, 5-isomer
Cyclooctyne derivative of tetramethylrhodamine (TMR, TAMRA) for copper-free click chemistry conjugation with azides. Pure 5-isomer.
Show pricing
| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| 171F0 | 1 mg | $125 | in stock | |
| 271F0 | 5 mg | $395 | in stock | |
| 471F0 | 25 mg |
$890
|
in stock | |
| 571F0 | 50 mg |
$1490
|
in stock | |
| 671F0 | 100 mg |
$1990
|
in stock |
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