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Oligonucleotide synthesis reagents

Oligonucleotide synthesis reagents / product groups & items in this category
Reagents for oligonucleotide synthesis.

FAM amidites and supports

Fluorescein phosphoramidites and supports used for 3'-, internal, and 5'-modification of oligonucleotides.
Group tags FAM (Fluorescein), Phosphoramidites, Oligonucleotide synthesis, CPG modifier solid supports

Cyanine phosphoramidites

Cyanine dye phosphoramidites for the synthesis of 5'-modified oligos.
Group tags Cyanine5, Phosphoramidites, Cyanine3, Cyanine5.5, Oligonucleotide synthesis

Xanthene amidites and supports (except FAM)

Phosphoramidite reagents for oligonucleotide labeling with xanthene dyes other than fluorescein.
Group tags TET (Tetrachlorofluorescein), Phosphoramidites, JOE, TAMRA (TMR, Tetramethylrhodamine), R6G, VIC, Oligonucleotide synthesis, CPG modifier solid supports, SIMA (Dichloro-diphenyl-fluorescein), HEX (Hexachlorofluorescein)

Quencher phosphoramidites and supports

Solid supports with fluorescence quenchers, and phosphoramidites for the labeling of terminal and internal positions of the oligonucleotide.
Group tags DusQ 21, DusQ 1, DusQ 2, DusQ 3, Phosphoramidites, Oligonucleotide synthesis, CPG modifier solid supports
  • DusQ 1 CPG 1000
    Controlled pore glass (CPG) 1000 solid support for synthesis of oligonucleotides with 3’-terminal DusQ1 quencher. Compatible with standard deblocking conditions.
  • DusQ 1 CPG 500
    Controlled pore glass (CPG) 500 solid support for the synthesis of oligonucleotides with 3’-terminal DusQ 1 quencher. Compatible with standard deblocking conditions.
  • DusQ 1 amidite, 5'-terminal
    Terminal phosphoramidite for labeling oligonucleotides at the 5' end with DusQ 1 quencher.
  • DusQ 1 dT phosphoramidite
    A phosphoramidite used for DusQ 1 dT labelling of oligonucleotides.
  • DusQ 1 phosphoramidite
    A black quencher dye phosphoramidite for the synthesis of oligonucleotide probes labeled with DusQ 1 quenchers at 5’-terminal. Useful for HEX, JOE, ROX, Cyanine3.
  • DusQ 2 CPG 1000
    Controlled pore glass (CPG) 1000 modified support for the synthesis of oligonucleotides with DusQ 2 quencher at the 3’ end. Compatible with standard deblocking conditions.
  • DusQ 2 CPG 500
    Controlled pore glass (CPG) 500 modified support for the synthesis of oligonucleotides with DusQ 2 quencher at the 3’ end. Compatible with standard deblocking conditions.
  • DusQ 2 dT phosphoramidite
    A phosphoramidite used for DusQ 2 dT labelling of oligonucleotides.
  • DusQ 2 phosphoramidite
    DusQ 2 phosphoramidite for the synthesis of oligonucleotides labeled with DusQ 2 quencher at 3'-end, 5'-end and internal position. The phosphoramidite has DMT protection and can be used for cartridge purification.
  • DusQ 21 CPG 500
    DusQ 21 is a quencher for dyes in red part of the spectrum, including Cyanine5 and Cyanine5.5.
  • DusQ 3 CPG 500
    DusQ 3 is a dark quencher for far red and near infrared dyes like Cyanine5.5. This is a controlled pore glass solid support for the synthesis of oligonucleotides with the quencher attached to 3'-terminus.

Universal solid supports

Non-nucleosidic controlled pore glass (CPG) support with universal linkers for the solid phase oligonucleotide automated synthesis of the sequence with any nucleoside at 3'-terminus.
Group tags Oligonucleotide synthesis, CPG modifier solid supports
  • MGB CPG 1000
    MGB CPG 1000 for the synthesis of oligonucleotides bearing dihydropyrroloindole tripeptide for binding to the DNA minor groove.
  • Universal CPG type II, 1000A
    This universal support is intended for automated synthesis of oligonucleotides to accelerate the dephosphorylation process during deblocking. Pore size of 1000 Å is recommended for the synthesis of oligonucleotides up to 120 bases.
  • Universal CPG type II, 500A
    This universal support is intended for automated synthesis of oligonucleotides for short-term dephosphorylation process during deblocking. Pore size of 500 Å is recommended for the synthesis of oligonucleotides up to 50 bases.

Click chemistry amidites and supports

Phosphoramidites and solid supports for the synthesis of oligonucleotides with azide and alkyne groups capable of downstream Click chemistry modification.
Group tags Cycloalkenes, Copper-free click chemistry, Cycloalkynes, Phosphoramidites, Azides, Alkynes, Oligonucleotide synthesis, CPG modifier solid supports, Click chemistry
  • 3'-Azido-modifier CPG 1000A
    Controlled pore glass solid support for DNA/RNA synthesis with azide modification (pore size 1000 Å) for the synthesis of long modified oligonucleotides with 3'-azide modification.
  • Alkyne CPG 1000A
    Controlled pore glass solid support for DNA/RNA synthesis with alkyne modification (pore size 1000 Å) for synthesizing long-modified oligonucleotides with 3'-alkyne modification.
  • Alkyne CPG modifier 500
    Solid support for the synthesis of 3'-modified oligonucleotides with alkyne group for Click Chemistry.
  • Alkyne amidite, hydroxyprolinol
    Acetylenic amidite for the incorporation of acetylene groups into oligos.
  • Alkyne dT phosphoramidite
    Phosphoramidite modifier for synthesizing oligonucleotides containing alkyne modification in the middle of the chain.
  • Alkyne phosphoramidite, 5'-terminal
    Alkyne phosphoramidite for the synthesis of oligonucleotides ready for click chemistry.
  • Alkyne-PEG4-phosphoramidite
    Alkyne phosphoramidite for conjugation of oligonucleotides with biomolecules.
  • C8-Alkyne-dT-CE-phosphoramidite
    C8-Alkyne-dT-CE-phosphoramidite is a specialized reagent used in the synthesis of oligonucleotides that incorporates a single dT alkyne group. This compound is particularly valuable for applications involving click chemistry, allowing for efficient conjugation reactions.
  • DBCO-TEG-phosphoramidite
    5'-DBCO-TEG-phosphoramidite for the synthesis of DBCO-TEG-modified oligos used in copper-free click reactions.
  • TCO phosphoramidite C6
    Trans-cyclooctene (TCO) amidite is used to introduce a TCO moiety into substrates containing primary or secondary hydroxyl group
  • endo-BCN CE-phosphoramidite
    BCN-containing phosphoramidite for the synthesis of oligonucleotides and their labeling using copper-free click reactions.
  • exo-BCN CE-phosphoramidite
    BCN-containing phosphoramidite for the synthesis of oligonucleotides and their labeling using copper-free click reactions.

Phosphorylation amidites and supports

Reagents and solid supports for the solid phase synthesis of 3'- and 5’-phosphorylated oligonucleotides.
Group tags Phosphoramidites, Oligonucleotide synthesis, CPG modifier solid supports

Amino amidites and supports

Reagents for the synthesis of amino modified oligonucleotides, which can be further modified or immobilized on certain solid supports.
Group tags Phosphoramidites, Oligonucleotide synthesis, CPG modifier solid supports

Biotinylation amidites and supports

Phosphoramidites and solid supports for the incorporation of biotin moiety into oligonucleotides.
Group tags Biotinylation, Phosphoramidites, CPG modifier solid supports

Spacer phosphoramidites

Spacer modifiers to insert linkers and spacer arms into oligonucleotides, and to prepare branched oligonucleotides.
Group tags Phosphoramidites, Oligonucleotide synthesis
  • Abasic phosphoramidite
    Abasic phosphoramidite for DNA synthesis and DNA damage and repair study.
  • C6 Spacer phosphoramidite
    Spacer 6 phosphoramidite, commonly referred to as C6 spacer amidite, is a specialized reagent used in the synthesis of oligonucleotides. This compound incorporates a 6-carbon hydrophobic spacer into oligonucleotide sequences, either internally or at the 5' end.
  • Hexaethylene glycol phosphoramidite
    Spacer phosphoramidite 18 (hexaethylene glycol amidite) provides a long hydrophilic linker for oligo synthesis.
  • Long trebler phosphoramidite
    Long trebler phosphoramidite is a branching reagent for DNA synthesis, allowing to prepare branched oligonucleotides, and dendrimers.

Polyaromatic phosphoramidites

Phosphoramidites with polycyclic aromatic hydrocarbons (PAHs) moieties for the introduction of polyaromatic residues in solid-phase synthesised oligonucleotides.
Group tags Phosphoramidites, Pyrene, Oligonucleotide synthesis

Modified nucleobase amidites

Non-standard nucleobase phosphoramidites suitable for solid phase synthesis of modified oligonucleotides.
Group tags Phosphoramidites, Oligonucleotide synthesis

Sulfurization reagents

Reagents for the synthesis of phosphothioate oligomers via amidite chemistry.
Group tags Oligonucleotide synthesis
  • DDTT Sulfurizing Reagent
    DDTT Sulfurizing Reagent for the fast and efficient production of phosphorothioate oligonucleotides (PTOs).
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