endo-BCN CE-phosphoramidite
| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
|
3005-100mg
/ septum vial
|
100 mg |
$399.90
|
in stock | |
|
3005-250mg
/ septum vial
|
250 mg |
$999.62
$889.90
|
in stock | |
|
3005-1g
/ septum vial
|
1 g |
$2380.00
|
in stock |
Bicyclononyne (BCN) is a stable and one of the most reactive cyclooctynes for copper-free click chemistry. Unlike dibenzocyclooctyne (DBCO), BCN is reactive both to azides (strain-promoted azyde-alkyne cycloaddition, SPAAC) and tetrazines (inverse electron demand Diels-Alder reaction, IEDDA). Being an endo-stereoisomer, bicyclononine in endo-BCN CE-phosphoramidite provides not significantly different rate of cycloaddition compared to its exo-conformer.
BCN-labeled oligonucleotides may be used for the conjugation to azide- or tetrazine-containing solid surfaces, polymers, and large proteins.
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General properties
| Appearance: | yellowish oil |
| Mass spec M+ increment: | 343.11 |
| Molecular weight: | 481.57 |
| CAS number: | 1352811-59-6 |
| Molecular formula: | C24H40F1N3O5P |
| Solubility: | good in acetonitrile |
| Quality control: | NMR 1H and 31P (95 %) |
| Storage conditions: | Storage: 12 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate. |
| MSDS: | Download |
| Product specifications |
Oligo synthesis details
| Diluent: | anhydrous acetonitrile |
| Coupling conditions: | coupling time 6 minutes. Oxidation: 0.5M (1S)-(+)-(10-camphorsulfonyl)-oxaziridine (CSO) in dry acetonitrile, 2 minutes. The modification is incompatible with iodine oxidation. Exclude the dimethoxytrityl (DMT) removal step (as in DMT-on protocol), because the modification is acid sensitive. |
| Deprotection conditions: | AMA (40% aq. methylamine, 25% ammonia, 1:1 mixture), 2 hours, room temperature |
This Product is offered and sold for research purposes only. It has not been tested for safety and efficacy in food, drug, medical device, cosmetic, commercial or any other use. Supply does not express or imply authorization to use for any other purpose, including, without limitation, in vitro diagnostic purposes, in the manufacture of food or pharmaceutical products, in medical devices or in cosmetic products.
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