Alkyne CPG modifier 500
Cat. # | Quantity | Price | Lead time | Buy this product |
---|---|---|---|---|
12860 | 100 mg | $60 | in stock | |
22860 | 250 mg | $120 | in stock | |
32860 | 500 mg | $230 | in stock | |
42860 | 1 g | $380 | in stock | |
52860 | 5 g | $1450 | in stock |
High loading controlled pore glass solid support for the synthesis of oligonucleotides with 3'-alkyne group. With this solid support, synthesis of oligos of up to 50 bases is possible.
Terminal alkyne group can be modified by copper catalyzed Click chemistry (see our recommended protocol for oligonucleotide modification).
This solid support is compatible with standard oligonucleotide deblocking conditions. No special deblocking is required.
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Controlled pore glass solid support for DNA/RNA synthesis with alkyne modification (pore size 1000 Å) for synthesizing long-modified oligonucleotides with 3'-alkyne modification.AF 488 azide
AF 488 azide is a fluorophore with emission in the green spectrum range. It reacts with alkynes in copper-catalyzed cycloaddition reactions.General properties
Appearance: | off-white beads |
Quality control: | NMR 1H and HPLC (95%) of bound reagent, loading measurement |
Storage conditions: | Storage: 24 months after receival at -20°C. Transportation: at room temperature for up to 3 weeks. Desiccate. |
MSDS: | Download |
Product specifications |
Oligo synthesis details
Pore size, Å: | 500 |
Typical loading, umol/g: | 70−90 |
Coupling conditions: | standard coupling, identical to normal nucleobases |
Cleavage conditions: | ammonia, 2 h at room temperature |
Deprotection conditions: | identical to protected nucleobases |
Product citations
- Kolganova, N.A.; Tsvetkov, V.B.; Stomakhin, A.A.; Surzhikov, S.A.; Timofeev, E.N.; Varizhuk, I.V. Alpha-Deoxyguanosine to Reshape the Alpha-Thrombin Binding Aptamer. International Journal of Molecular Sciences, 2023, 24(9), 8406. doi: 10.3390/ijms24098406
- Petrunina, N.A.; Lebedev, V.V.; Kirillova, Y.G.; Aralov, A..V.; Varizhuk, A.M.; Sardushkin, M.V. DNA Intercalated Motifs with Non-Nucleoside Inserts. Russian Journal of Bioorganic Chemistry, 2021, 47(6), 1341–1344. doi: 10.1134/S1068162021060212
- Svetlova, J.; Sardushkin, M.; Kolganova, N.; Timofeev, E. Recognition Interface of the Thrombin Binding Aptamer Requires Antiparallel Topology of the Quadruplex Core. Biomolecules, 2021, 11(9), 1332. doi: 10.3390/biom11091332
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