DBCO-maleimide

Cycloalkynes Maleimides Copper-free click chemistry
Cat. # Quantity Price Lead time
4448-100mg 100 mg $319 in stock
4448-500mg 500 mg $1028 in stock
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DBCO-maleimide is a bifunctional linker containing a maleimide group and a DBCO (Dibenzocyclooctyne, ADIBO) moiety.

The maleimide group specifically and efficiently reacts with thiols to form thioether bonds. The low mass weight adds minimal spacer to modified molecules and enables the simple and efficient incorporation of the DBCO moiety into cysteine-containing peptides or other thiol-containing biomolecules.

DBCO is one of the most reactive cycloalkynes for strain-promoted alkyne azide cycloaddition (SPAAC). DBCO reacts instantly with azides without needing a Cu(I) catalyst, resulting in a stable triazole linkage. The reaction rate is much higher than that of copper-catalyzed reaction, and reactions with many other cyclooctynes. Unlike other cyclooctynes, DBCO does not react with tetrazines — this allows to carry out orthogonal conjugation of azides with DBCO and trans-cyclooctenes with tetrazines.

DBCO-maleimide, 4448-100mg
DBCO-maleimide, 4448-100mg
DBCO-maleimide, 4448-100mg
Structure of DBCO-maleimide
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DBCO-NHS ester

Azodibenzocyclooctyne (DBCO, ADIBO) reagent for strain-promoted copper-free click chemistry (SPAAC). The reagent contains an NHS ester function for the attachment of the cyclooctyne to various molecules.

Azide-PEG4-amine

PEG4 amine azide is a bifunctional linker with amine and azide functional groups. It is based on a tetraethyleneglycol core. The length of the PEG4 linker is 1.4 nm.

DBCO-PEG6-NHS ester

A heterobifunctional linker with DBCO and NHS ester function groups flanking PEG6 (hexaethylene glycol).

General properties

Appearance: white solid
Molecular weight: 441.49
Molecular formula: C26H23N3O4
Solubility: methylene, DMSO, DMF, acetonitrile
Quality control: NMR 1H and HPLC-MS (95+%)
Storage conditions: 12 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Desiccate.
MSDS: Download
Product specifications
This Product is offered and sold for research purposes only. It has not been tested for safety and efficacy in food, drug, medical device, cosmetic, commercial or any other use. Supply does not express or imply authorization to use for any other purpose, including, without limitation, in vitro diagnostic purposes, in the manufacture of food or pharmaceutical products, in medical devices or in cosmetic products.
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