Cyanine3-PEG4-BCN (exo)

This product is discontinued, and no longer available.

Cyanine3-PEG4-BCNcontains functional group bicyclononyne linked to a fluorophore Cyanine3. Bicyclo[6.1.0]nonyne (BCN) is a cyclooctyne with a significantly improved reactivity profile of strain-promoted azide-alkyne cycloaddition.

Conjugation of cyclooctyne constructs is used for labeling monoclonal antibodies containing an azido-functionalized amino acid with high conversion via copper-free click conjugation [1].

[1] Remon van Geel et al. Chemoenzymatic Conjugation of Toxic Payloads to the Globally Conserved N-Glycan of Native mAbs Provides Homogeneous and Highly Efficacious Antibody–Drug Conjugates. Bioconjugate Chemistry. 2015. 26(11). P.2233-2242.

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Alkyne-PEG3-NHS ester

Bifunctional hydrophilic linker with NHS ester and terminal alkyne functional group based on triethyleneglycol (PEG3).
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Azide-PEG4-amine

PEG4 amine azide is a bifunctional linker with amine and azide functional groups. It is based on a tetraethyleneglycol core. The length of the PEG4 linker is 1.4 nm.

General properties

Appearance: dark red paste
Molecular weight: 1014.79
Molecular formula: C58H84ClN5O8
Quality control: NMR 1H and HPLC-MS (95+%)
Storage conditions: 24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Desiccate. Avoid prolonged exposure to light.
MSDS: Download
Product specifications
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