BCN-PEG4-Cyanine3 (exo)
Cat. # | Quantity | Price | Lead time | Buy this product |
---|---|---|---|---|
3269-5mg | 5 mg | please inquire | in stock (4 pcs) | |
3269-50mg | 50 mg | please inquire | in stock (2 pcs) |
BCN-PEG4-Cyanine3 contains functional group bicyclononyne linked to a fluorophore Cyanine3. Bicyclo[6.1.0]nonyne (BCN) is a cyclooctyne with a significantly improved reactivity profile of strain-promoted azide-alkyne cycloaddition.
Conjugation of cyclooctyne constructs is used for labeling monoclonal antibodies containing an azido-functionalized amino acid with high conversion via copper-free click conjugation [1].
[1] Remon van Geel et al. Chemoenzymatic Conjugation of Toxic Payloads to the Globally Conserved N-Glycan of Native mAbs Provides Homogeneous and Highly Efficacious Antibody–Drug Conjugates. Bioconjugate Chemistry. 2015. 26(11). 2233-2242.
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General properties
Appearance: | dark red powder |
Molecular weight: | 1014.79 |
Molecular formula: | C58H84ClN5O8 |
Quality control: | NMR 1H and HPLC-MS (95+%) |
Storage conditions: | 24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Desiccate. Avoid prolonged exposure to light. |
MSDS: | Download |
Product specifications |