Cyanine5 carboxylic acid
| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| 13090 | 1 mg |
$110.00
|
in stock | |
| 23090 | 5 mg |
$210.00
|
in stock | |
| 43090 | 25 mg |
$449.90
|
in stock | |
| 53090 | 50 mg |
$769.90
|
in stock | |
| 63090 | 100 mg |
$1190.00
|
in stock |
Non-activated carboxylic acid, an analog of Cy5® free carboxylic acid. Contains Cyanine5 fluorophore.
This dye has limited water solubility, but can be dissolved in mixtures of water with organic phase (DMF, DMSO, alcohols) to obtain useful concentrations of the material in solution. Water-soluble version is available.
This molecule can be considered non-reactive dye for the use in control samples, and for instrument calibration. For coupling with amines and protein labeling, consider using Cyanine5 NHS ester, or water-soluble sulfo-Cyanine5 NHS ester.
Cyanine5 absorbance and emission spectra
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General properties
| Appearance: | dark golden solid |
| Molecular weight: | 519.12 |
| CAS number: | 1032678-07-1 (chloride), 195867-59-5 (inner salt), 766503-38-2 (without anion) |
| Molecular formula: | C32H39ClN2O2 |
| IUPAC name: | 3H-Indolium, 2-[5-[1-(5-carboxypentyl)-1,3-dihydro-3,3-dimethyl-2H-indol-2-ylidene]-1,3-pentadien-1-yl]-1,3,3-trimethyl-, chloride |
| Solubility: | soluble in organic solvents (DMF, DMSO, dichloromethane), very poorly soluble in water (0.25 mM, 130 mg/L) |
| Quality control: | NMR 1H, HPLC-MS (95%) |
| Storage conditions: | Storage: 24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate. |
| MSDS: | Download |
| Product specifications |
Spectral properties
| Excitation/absorption maximum, nm: | 646 |
| ε, L⋅mol−1⋅cm−1: | 250000 |
| Emission maximum, nm: | 662 |
| Fluorescence quantum yield: | 0.2 |
| CF260: | 0.03 |
| CF280: | 0.04 |
Product citations
- Tsanaktsidou, E.; Margaroni, M.; Karagouni, E.; Kiparissides, C.; Kammona, O. In Vitro Assessment of a Doubly Adjuvanted Self-Emulsified Nanoemulsion as a Delivery Vehicle for Antigenic Proteins. Pharmaceutics, 2025, 17(7), 870. doi: 10.3390/pharmaceutics17070870
- Carreira, B.; Acúrcio, R. C.; Matos, A. I.; Moura, L. I. F.; Afonso, M. B.; Viana, A. S.; Santos, F. M. F.; Gois, P. M. P.; Rodrigues, C. M. P.; Guedes, R. C.; Satchi-Fainaro, R.; Florindo, H. F. Polymeric-Based Neoantigen Nanovaccine Synergizes with PD-1/PD-L1 Modulators, Reprogramming the Melanoma Microenvironment. Journal of Controlled Release, 2025, 387, 114178. doi: 10.1016/j.jconrel.2025.114178
- Tchatchiashvilli, T.; Duering, H.; Mueller-Boetticher, L.; Grune, C.; Fischer, D.; Pletz, M.W.; Makarewicz, O. PEG-PLGA nanoparticles deposited in Pseudomonas aeruginosa and Burkolderia cenocepacia. Journal of Pharmaceutical Analysis, 2024, 14(12), 100939. doi: 10.1016/j.jpha.2024.01.007
- Mamani, U.-F.; Ibrahim, M. N.; Liu, Y.; Fetse, J.; Lin, C.-Y.; Kandel, S.; Nakhjiri, M.; Koirala, S.; Guo, Y.; Alahmari, M.; Cheng, K. Exploring Multivalency in the Development of Anti-PD-L1 Peptides for Cancer Immunotherapy. Pharmaceutical Research, 2024, 41(12), 2275–2288. doi: 10.1007/s11095-024-03803-1
Cy® is a trademark of GE Healthcare.
This Product is offered and sold for research purposes only. It has not been tested for safety and efficacy in food, drug, medical device, cosmetic, commercial or any other use. Supply does not express or imply authorization to use for any other purpose, including, without limitation, in vitro diagnostic purposes, in the manufacture of food or pharmaceutical products, in medical devices or in cosmetic products.
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