VHL Ligand 1 dihydrochloride

PROTAC

Cat. #	Quantity	Price	Lead time
4065-250mg	250 mg	$175	in stock
4065-500mg	500 mg	$258	in stock
4065-1g	1 g	$469	in stock

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Proteolysis targeting chimeras (PROTACs) are cell-permeable heterobifunctional molecules that can remove specific proteins from the cell. One end of such molecule contains a ligand to bind to the target, and the second end recruits the E3 ligase complex. Close proximity results in substrate polyubiquitination and subsequent protein degradation by cellular proteasome.

VHL Ligand 1 (VH032-NH2, (S,R,S)-AHPC) is a synthetic E3 ligase ligand that is used as a building block for the synthesis of proteolysis-targeting chimera (PROTAC) molecules.

Structure of VHL Ligand 1 dihydrochloride

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Degrader building block containing an E3 ligase ligand with linker and azide group, which can be conjugated to alkyne-functionalized linkers and target protein ligands through click chemistry reactions.

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Thalidomide-containing building block with carboxylic acid functionality for convenient PROTAC molecule assembly by attachment amino-functionalized linkers and ligands to thalidomide via 4-O-position.

General properties

Appearance:	yellow-brown powder
Molecular weight:	503.50
CAS number:	1448189-80-7 (monohydrochloride)
Molecular formula:	C₂₂H₃₂Cl₂N₄O₃S
IUPAC name:	(4R)-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-L-prolinamide, dihydrochloride
Solubility:	methanol, DCM, DMF, DMSO
Quality control:	NMR ¹H and HPLC-MS (95+%)
Storage conditions:	24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Desiccate.
MSDS:	Download
	Product specifications

This Product is offered and sold for research purposes only. It has not been tested for safety and efficacy in food, drug, medical device, cosmetic, commercial or any other use. Supply does not express or imply authorization to use for any other purpose, including, without limitation, in vitro diagnostic purposes, in the manufacture of food or pharmaceutical products, in medical devices or in cosmetic products.

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