Thalidomide-carboxylic acid

Carboxylic acids Crosslinking PROTAC

Cat. #	Quantity	Price	Lead time
4169-100mg	100 mg	$160	in stock
4169-500mg	500 mg	$510	in stock
4169-1g	1 g	$740	in stock

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Thalidomide-containing building block with carboxylic acid functionality for convenient PROTAC molecule assembly by attachment amino-functionalized linkers and ligands to thalidomide via 4-O-position.

Proteolysis targeting chimeras (PROTACs) are cell-permeable heterobifunctional molecules that can remove specific proteins from the cell. One end of such molecule contains a ligand to bind to the target, and the second end recruits the E3 ligase complex. Close proximity results in substrate polyubiquitination and subsequent protein degradation by cellular proteasome.

There are several types of E3 ligases that are practically suitable for such a purpose. Thalidomide is the ligand capable of recruiting Cereblon (CRBN) E3 ligase.

Structure of Thalidomide-carboxylic acid

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General properties

Appearance:	beige powder
Molecular weight:	332.27
CAS number:	1061605-21-7
Molecular formula:	C₁₅H₁₂N₂O₇
Solubility:	DMF, DMSO
Quality control:	NMR ¹H and HPLC-MS (95+%)
Storage conditions:	24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Desiccate.
MSDS:	Download
	Product specifications

Product is offered and sold for research purposes only. Product is not tested for safety and efficacy in food, drug, medical device, cosmetic, no express or implied authorization to use for any other purpose, including, without limitation, in vitro diagnostic purposes, for humans or animals or for commercial purposes.

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