Disuccinimidyl glutarate (DSG)
| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| 4018-100mg | 100 mg | $95 | in stock | |
| 4018-1g | 1 g |
$410
|
in stock |
Disuccinimidyl glutarate (DSG) is a homobifunctional crosslinker that contains two N-hydroxysuccinimide (NHS) ester groups at each end of a short 5-atom (7.7 angstrom) spacer.
DSG is a membrane-permeable and non-cleavable crosslinker, allowing for intracellular labeling of peptides and proteins. NHS esters react with amines of lysine residues and N-termini of peptides and proteins, forming a covalent amide bond and releasing the NHS group. DSG is commonly used to pair radiolabelled ligands to cell surface receptors and determine DNA-protein binding interactions in ChIP assays. DSG labeling is often combined with formaldehyde fixation to improve the detection of DNA-protein complexes.
DSG is water-insoluble and must be dissolved in an organic solvent, such as DMSO or DMF, before being added to aqueous solutions.
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General properties
| Appearance: | off-white powder |
| Molecular weight: | 326.26 |
| CAS number: | 79642-50-5 |
| Molecular formula: | C13H14N2O8 |
| IUPAC name: | Bis(2,5-dioxopyrrolidin-1-yl) Pentanedioate |
| Solubility: | DMF, DMSO |
| Quality control: | NMR 1H and HPLC-MS (95+%) |
| Storage conditions: | 12 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Desiccate. |
| MSDS: | Download |
| Product specifications |
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