C26:0-lysophosphatidylcholine (LPC)

Cat. # Quantity Price Lead time
4929-5mg 5 mg $489 12 days
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Lysopc(26:0), also known as LysoPC a C26:0, is classified as a member of the 1-acyl-sn-glycero-3-phosphocholines. 1-acyl-sn-glycero-3-phosphocholines are glycerophosphocholines in which the glycerol is esterified with a fatty acid at O-1 position, and linked at position 3 to a phosphocholine. Lysopc(26:0) can be used as internal standard LC-MS studies.

Lysophosphatidylcholines (LPCs) specifically bind to G protein-coupled receptors GPR119, GPR40, GPR55 and GPR4. Binding of LPCs to GPR119, GPR40 and GPR55 induces intracellular calcium mobilization and leads to increased glucose-stimulated insulin secretion in different cell systems. In blood or plasma LPCs are bound mainly to albumin and to a lesser extent to lipoproteins.

Inflammation, cell damage and other pathophysiological conditions can profoundly alter the ratio of free to albumin bound LPC through increased production of LPC or decreased plasma levels of albumin. In particular, lower levels of albumin (hypoalbuminemia) lead to lower levels of LPC in the blood. Lysopc(26:0) is a biomarker for X-linked Adrenoleukodystrophy (X-ALD). Lysopc(26:0) could be used as auxiliary marker for diagnosis of peroxisomal β-oxidation disorders.

Structure of Lyso-PC 26:0
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ChemDraw format

General properties

Appearance: white powder
Molecular weight: 635.90
CAS number: 1213783-80-2
Molecular formula: C34H70NO7P
IUPAC name: [(2R)-3-hexacosanoyloxy-2-hydroxypropyl] 2-(trimethylazaniumyl)ethyl phosphate
Quality control: NMR 1H and HPLC-MS (95+%)
Storage conditions: 24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Desiccate.
MSDS: Download
Product specifications
This Product is offered and sold for research purposes only. It has not been tested for safety and efficacy in food, drug, medical device, cosmetic, commercial or any other use. Supply does not express or imply authorization to use for any other purpose, including, without limitation, in vitro diagnostic purposes, in the manufacture of food or pharmaceutical products, in medical devices or in cosmetic products.
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