dU (Deoxyuridine) phosphoramidite
Cat. # | Quantity | Price | Lead time | Buy this product |
---|---|---|---|---|
320-1g | 1 g | $60 | in stock | |
320-10g | 10 g | $250 | in stock | |
320-50g | 50 g | please inquire | in stock |
dU amidite enables the addition of deoxyuridine nucleoside to the DNA chain to synthesize modified oligonucleotides. Deoxyuridine (dU) is a derivative of the nucleoside uridine and has H instead of hydroxy group at the 2’-position of the ribose. This amidite contains DMT at the 5’-end.
Oligos modification with dU affects the melting profiles of oligo duplexes via integrating 2’-deoxyuridine into nucleic acid sequences.
dU (Deoxyuridine) phosphoramidite can serve for oligonucleotide probes and as a research tool for duplex stability studies and those of DNA damage and repair mechanisms.
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General properties
Appearance: | white to pale yellow powder |
Molecular weight: | 730.79 |
CAS number: | 109389-30-2 |
Molecular formula: | C39H47N4O8P |
IUPAC name: | 5'-O-(4,4'-Dimethoxytrityl)-2'-deoxyuridine-3'-O-[O-(2-cyanoethyl)-N,N'-diisopropylphosphoramidite] |
Solubility: | good in acetonitrile, DCM |
Quality control: | NMR 1H, NMR 31P, HPLC-MS (95%) |
Storage conditions: | Storage: 12 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Desiccate. |
MSDS: | Download |
Product specifications |
Oligo synthesis details
Diluent: | acetonitrile |
Coupling conditions: | standard coupling, identical to normal nucleobases |
Cleavage conditions: | ammonia, 2 h at room temperature |
Deprotection conditions: | identical to protected nucleobases |