FCCP, ATPase inhibitor

Mitochondria
Cat. # Quantity Price Lead time
4632-1mg 1 mg $25 12 days
4632-10mg 10 mg $73 7 days
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FCCP (trifluoromethoxy carbonylcyanide phenylhydrazone, carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone) is a proton (H+) ionophore and a potent mitochondrial uncoupling agent, which lowers ROS production and Ca2+ overload. This compound turns the mitochondrial membrane permeable to protons, thus dissipating the mitochondrial membrane potential and uncoupling oxidative phosphorylation from ATP synthesis.

FCCP is widely used to analyze mitochondrial function in living tissues, cells, and isolated mitochondrial preparations. It is also used to investigate the mechanisms of autophagy by inducing mitochondrial degradation through the disruption of the mitochondrial membrane potential.

A low concentration of FCCP (1 μM) results in a complete loss of mitochondrial membrane potential without triggering mitophagy, whereas a high concentration (10 μM) leads to increased cytosol acidification, and mitochondrial degradation is attained.

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General properties

Appearance: bright yellow crystals
Molecular weight: 254.17
Molecular formula: C10H5F3N4O
IUPAC name: 2-[2-[4-(trifluoromethoxy)phenyl]hydrazinylidene]-propanedinitrile
Solubility: Soluble in DMSO (100 mM). Soluble in methanol, ethanol, and acetone to 20 mg/mL. Insoluble in water.
Quality control: NMR 1H and HPLC-MS (95+%)
Storage conditions: 24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Desiccate.
MSDS: Download
Product specifications
This Product is offered and sold for research purposes only. It has not been tested for safety and efficacy in food, drug, medical device, cosmetic, commercial or any other use. Supply does not express or imply authorization to use for any other purpose, including, without limitation, in vitro diagnostic purposes, in the manufacture of food or pharmaceutical products, in medical devices or in cosmetic products.
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