SR101 Astroglia Stain
| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| 3142-500mg | 500 mg |
$199.00
|
in stock |
Sulforhodamine 101 (SR101) is a water-soluble, photostable fluorescent dye widely used for labeling live astrocytes.
In live-cell imaging, extracellular application of SR101 results in its preferential uptake by astrocytes, facilitating clear visualization of their morphology and network integrity without significant staining of neurons. It makes SR101 an indispensable tool for in vivo studies of glial function and cytoarchitecture [1].
SR101 labels astrocytes primarily via an active transport mechanism involving the specific cellular transporter OATP1C1, which is preferentially expressed in astroglial cells. OATP1C1 selectivity is not absolute and can be influenced by several factors [2]. Also, SR101 can spread from astrocytes to mature oligodendrocytes via gap junctions [3].
SR101 can also be used as an effective fluorescent tracer to investigate vascular perfusion, gap junction permeability, and fluid dynamics, thanks to its high hydrophilicity and bright emission. Furthermore, its structural similarity to Rose Bengal allows it to function as an efficient photosensitizer in photodynamic therapy research.
[1] Nat. Methods. 2004. 1(1):31–37; [2] Brain Struct. Funct. 2015. 220:193–203; [3] Nat. Methods. 2014. 11(11):1081–1082.
Product in action
Glial cells labeled with Sulforhodamine 101 (SR101)
Excitation and emission spectra of LumiCell® SR101 Astroglia Stain
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General properties
| Appearance: | dark crystals |
| Molecular weight: | 606.72 |
| CAS number: | 60311-02-6 |
| Molecular formula: | C31H30N2O7S2 |
| Quality control: | NMR 1H and HPLC-MS (95+%) |
| Storage conditions: | 24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Desiccate. |
| MSDS: | Download |
| Product specifications |
Spectral properties
| Excitation/absorption maximum, nm: | 582 |
| Emission maximum, nm: | 600 |
| Fluorescence quantum yield: | 0.79 |
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