DND-167, blue fluorescent pH indicator

Lysosomes Microscopy

Cat. #	Quantity	Price	Lead time
S8410 / 1 mM solution	1 x 50 uL	–	1 days
28410 / 1 mM solution	5 x 50 uL	$115	1 days
18410 / 1 mM solution	20 x 50 uL	$380	21 days

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DND-167 (known as LysoSensor™ Blue DND-167, LysoView Blue) is a cell-permeable dye that selectively accumulates in acidic vesicles after being protonated. The dye has increased quantum yield in acidic environments allowing visualization of the lysosomes and late endosomes in living cells.

DND-167 is widely used as a pH indicator with pKa ~5.1. It has weak fluorescence at neutral pH but become much brighter at the blue region of spectra at acidic pH. An excitation/emission maxima of the dye at pH 3.0 are 370 and 425 nm, respectively.

The dye is supplied as a 1 mM solution in DMSO.

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General properties

Appearance:	yellowish solution
Molecular weight:	376.49
Molecular formula:
IUPAC name:	4-[[10-(morpholin-4-ylmethyl)anthracen-9-yl]methyl]morpholine
Solubility:	good in dichloromethane, limited in DMSO
Quality control:	NMR ¹H, HPLC-MS (95%)
Storage conditions:	24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Desiccate.
MSDS:	Download

This Product is offered and sold for research purposes only. It has not been tested for safety and efficacy in food, drug, medical device, cosmetic, commercial or any other use. Supply does not express or imply authorization to use for any other purpose, including, without limitation, in vitro diagnostic purposes, in the manufacture of food or pharmaceutical products, in medical devices or in cosmetic products.

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