Our PROTAC molecules for your targeted protein degradation
Proteolysis targeting chimeras (PROTACs) are cell-permeable heterobifunctional molecules that can remove specific proteins from the cell. One end of such molecule contains a ligand to bind to the target, and the second end recruits the E3 ligase complex. Close proximity results in substrate polyubiquitination and subsequent protein degradation by cellular proteasome.
Several types of E3 ligases are practically suitable for such a purpose. Thalidomide is a ligand capable of recruiting Cereblon (CRBN) E3 ligase. VHL Ligand 1 (VH032-NH2, (S, R, S)-AHPC) is a synthetic ligand for the von Hippel-Lindau (VHL) Cullin RING E3 ligase.
We offer PROTAC building blocks containing different ligase recruiters and reactive groups for attaching the PROTAC molecule to the specific ligand of the target protein.
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VHL Ligand 1 dihydrochloride |
(S,R,S)-AHPC-PEG2-C2-azide |
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(S,R,S)-AHPC-amido-C2-carboxylic acid |
Thalidomide-O-PEG2-amine |
More PROTAC building blocks are in our catalog.
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