sulfo-Cyanine5 TCO
| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| 133H0 | 1 mg |
$290.00
|
in stock | |
| 233H0 | 5 mg |
$348.00
|
in stock | |
| 333H0 | 10 mg |
$578.00
|
in stock | |
| 433H0 | 25 mg |
$1220.00
|
in stock |
sulfo-Cyanine5 TCO is a water-soluble far-red fluorescent dye derived from sulfo-Cyanine5 and functionalized with a trans-cyclooctene (TCO) group. The molecule is designed for rapid and highly selective bioorthogonal labeling of tetrazine-containing biomolecules via the inverse electron-demand Diels—Alder (IEDDA) reaction.
The sulfo-Cyanine5 fluorophore belongs to the family of cyanine dyes emitting in the far-red region of the spectrum and is characterized by high molar absorptivity, a good quantum yield, and excellent photostability. The presence of two sulfonate groups provides high water solubility and reduces nonspecific interactions with biomolecules, making the dye well-suited for biological applications.
The trans-cyclooctene moiety enables exceptionally fast reaction kinetics with tetrazines, allowing efficient labeling at low reagent concentrations and under mild conditions, including experiments with live cells.
Absorbance and emission spectra of sulfo-Cyanine5
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General properties
| Appearance: | deep-blue crystals |
| Molecular weight: | 931.27 |
| Molecular formula: | C47H63KN4O9S2 |
| Solubility: | water, DMSO, DMF |
| Quality control: | NMR 1H and HPLC-MS (95+%) |
| Storage conditions: | 24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Desiccate. Avoid prolonged exposure to light. |
| MSDS: | Download |
| Product specifications |
Spectral properties
| Excitation/absorption maximum, nm: | 646 |
| ε, L⋅mol−1⋅cm−1: | 271000 |
| Emission maximum, nm: | 662 |
| Fluorescence quantum yield: | 0.28 |
| CF260: | 0.04 |
| CF280: | 0.04 |
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