TCO-PEG4-NHS ester (axial isomer)

NHS esters Copper-free click chemistry Cycloalkenes Protein labeling
Cat. # Quantity Price Lead time
3056-10mg 10 mg $145 in stock
3056-25mg 25 mg $225 in stock
3056-100mg 100 mg $550 in stock
Bulk inquiry
Found better price? Let us know and we will propose the way forward!

TCO-PEG4-NHS ester is a bifunctional linker with trans-cyclooctene (TCO) and NHS ester groups flanking PEG4 (tetraethylene glycol).

The PEG spacer increases solubility in aqueous media and provides a long and flexible connection that minimizes steric hindrance involved with ligation.

The amine-reactive N-hydroxysuccinimide residue provides easy attachment to almost any primary or secondary amine group, such as protein, peptide, or small molecule amine.

Trans-cyclooctene readily reacts with tetrazines via inverse electron-demand Diels-Alder cycloaddition (IEDDA). TCO-Tetrazine ligation possesses ultrafast kinetics, selectivity, and long-term aqueous stability, which is important in low-concentration applications such as protein-protein conjugations, etc.

TCO-PEG4-NHS ester (axial isomer), 3056-100mg
TCO-PEG4-NHS ester (axial isomer), 3056-100mg
TCO-PEG4-NHS ester (axial isomer), 3056-100mg
Structure of TCO-PEG4-NHS ester
Download in
ChemDraw format

Recommended protocol

Calculator

Customers also purchased with this product

Cyanine3 DBCO

Cyanine3 dibenzocyclooctyne (DBCO, or ADIBO) is a cycloalkyne dye derivative for copper-free click chemistry.

sulfo-Cyanine7 tetrazine

Near infrared, water soluble dye methyltetrazine for the conjugation with strained cycloalkenes in TCO ligation reaction.

AmdU (5-Azidomethyl-2'-deoxyuridine)

Azidomethyldeoxyuridine (AmdU) is an azide-contained nucleoside that is incorporated into nascent DNA by cellular polymerases. The azide groups attached to DNA this way can be subsequently modified with alkynes or cycloalkynes via copper-catalyzed or strain-promoted click reaction.

General properties

Appearance: colorless syrup
Molecular weight: 514.57
CAS number: 1621096-79-4
Molecular formula: C24H38N2O10
Solubility: DMSO, DMF, THF, Acetonitrile, Dichloromethane
Quality control: NMR 1H and HPLC-MS (95+%)
Storage conditions: 12 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Desiccate.
MSDS: Download
Product specifications
This Product is offered and sold for research purposes only. It has not been tested for safety and efficacy in food, drug, medical device, cosmetic, commercial or any other use. Supply does not express or imply authorization to use for any other purpose, including, without limitation, in vitro diagnostic purposes, in the manufacture of food or pharmaceutical products, in medical devices or in cosmetic products.
Your item has been added. View your cart or proceed to checkout
The count of items is incorrect.