Disuccinimidyl glutarate (DSG)
| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| 4018-100mg | 100 mg | $95 | in stock | |
| 4018-1g | 1 g |
$410
|
in stock |
Disuccinimidyl glutarate (DSG) is a homobifunctional crosslinker that contains two N-hydroxysuccinimide (NHS) ester groups at each end of a short 5-atom (7.7 angstrom) spacer.
DSG is a membrane-permeable and non-cleavable crosslinker, allowing for intracellular labeling of peptides and proteins. NHS esters react with amines of lysine residues and N-termini of peptides and proteins, forming a covalent amide bond and releasing the NHS group. DSG is commonly used to pair radiolabelled ligands to cell surface receptors and determine DNA-protein binding interactions in ChIP assays. DSG labeling is often combined with formaldehyde fixation to improve the detection of DNA-protein complexes.
DSG is water-insoluble and must be dissolved in an organic solvent, such as DMSO or DMF, before being added to aqueous solutions.
Recommended protocol
Calculator
Customers also purchased with this product
AF 488 DBCO
Dibenzocyclooctyne (DBCO, ADIBO) containing the green fluorophore AF 488 for labeling azide-tagged biomolecules inside live cells, whole organisms, and inanimate samples. Pure 5-isomer.sulfo-Cyanine5 bis-NHS ester
Water soluble amine reactive Cyanine5 dye with two NHS ester groups.Biotin-PEG4-NHS ester
PEG4-containing activated ester for simple and efficient biotin labeling of antibodies, proteins, and other primary amine-containing biomolecules.General properties
| Appearance: | off-white powder |
| Molecular weight: | 326.26 |
| CAS number: | 79642-50-5 |
| Molecular formula: | C13H14N2O8 |
| IUPAC name: | Bis(2,5-dioxopyrrolidin-1-yl) Pentanedioate |
| Solubility: | DMF, DMSO |
| Quality control: | NMR 1H and HPLC-MS (95+%) |
| Storage conditions: | 12 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Desiccate. |
| MSDS: | Download |
| Product specifications |
Your cart is empty
$ 
