Bis-ANS, protein conformation probe

Cat. # Quantity Price Lead time
4381-5mg 5 mg $159 in stock
4381-25mg 25 mg $397 in stock
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Bis-ANS is a high-affinity fluorescent probe for nonpolar cavities in proteins. Its hydrophobic phenyl and naphthyl rings interact noncovalently with proteins and protein degradation products.

As with other anilinonaphthalene sulfonates (ANS), bis-ANS is essentially nonfluorescent in water but becomes noticeably fluorescent in a nonpolar environment. When free, bis-ANS has an excitation maximum at 390 nm and an emission maximum at 523 nm but undergoes a blue shift with an increase in fluorescence intensity when bound to protein.

Bis-ANS is frequently used to monitor the formation of protein aggregates and indicate protein folding and conformational changes. The dye is also used to detect Aβ fibers.

Excitation and emission spectra of protein complex with Bis-ANS

Excitation and emission spectra of protein complex with Bis-ANS

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General properties

Appearance: light yellow-green crystals
Molecular weight: 672.87
CAS number: 65664-81-5
Molecular formula: C32H22K2N2O6S2
IUPAC name: dipotassium;8-anilino-5-(4-anilino-5-sulfonatonaphthalen-1-yl)naphthalene-1-sulfonate
Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, ethanol: slightly soluble, PBS (pH 7.2): 5 mg/ml
Quality control: NMR 1H and HPLC-MS (95+%)
Storage conditions: 24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Desiccate.
MSDS: Download
Product specifications

Spectral properties

Excitation/absorption maximum, nm: 396 (free), 401 (complex)
Emission maximum, nm: 508 (free), 488 (complex)
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