MemBlaze® 640, deep-red fluorescent membrane probe
| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
|
15M10
/ 50-300 slides
|
2 nmol |
$240.00
|
in stock | |
|
25M10
/ 250-1500 slides
|
10 nmol |
$450.00
|
in stock |
MemBlaze® 640 is a far-red fluorogenic plasma membrane probe, a member of the MEMBRIGHT® [1] family, designed for high-contrast labeling of live and fixed cells. The dye is based on a lipophilic cyanine scaffold bearing amphiphilic membrane-anchoring groups that facilitate rapid, selective insertion into lipid bilayers.
In aqueous media, MemBlaze® 640 forms weakly fluorescent aggregates. Upon interaction with biological membranes, fluorescence is strongly activated, providing bright, uniform plasma membrane staining with exceptionally low background. The fluorogenic mechanism enables wash-free protocols and high signal-to-noise ratios even at nanomolar working concentrations.
MemBlaze® 640 demonstrates minimal internalization under standard staining conditions and preserves membrane integrity. The probe exhibits high photostability and low cytotoxicity, making it suitable for long-term and time-lapse imaging experiments.
The dye is optimized for standard far-red filter sets (excitation ~650 nm, emission ~670-680 nm) and can be readily combined with other fluorescent probes for multicolor imaging using widefield, confocal, spinning disk, TIRF, and super-resolution microscopy.
[1] Cell Chem. Biol. 2019, 26, 4, 600–614.
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General properties
| Appearance: | blue solid |
| Molecular weight: | 1423.86 |
| Molecular formula: | C73H119IN10O6S2 |
| Solubility: | DMSO, DMF |
| Quality control: | NMR 1H and HPLC-MS (95+%) |
| Storage conditions: | 24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Desiccate. |
| MSDS: | Download |
| Product specifications |
Spectral properties
| Excitation/absorption maximum, nm: | 648 |
| Emission maximum, nm: | 669 |
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